Three-dimensional (3D) digitization of morphology is increasing familiarly with technological developments. Once data is digitized, even the complex structures can be precisely and comprehensively quantified, reshaped, or 3D printed. Thus, these technologies make the diagnosis, treatment, and research safer and more accessible by replacing invasive imaging techniques or reducing the cost of expensive modeling procedures. It is also perfect for creating virtual models of new designs inspired by nature with reverse engineering applications and simulating its functions in different conditions. Moreover, recording 3D geometry and texture of objects in the digital environment allows detailed documentation of critical data and the creation of libraries for educational, scientific, clinical, or forensic purposes. Several varieties of 3D digitization methods and devices are available for particular purposes, such as data obtaining principles, light sources, sizes, and sensitivity. Due to all the factors mentioned above, 3D technologies bring new perspectives to many disciplines in solving problems. This Methods Collection provides details of state-of-the-art 3D morphometry digitizing and analyzes methodologies that can replace or develop conventional scientific interventions.