More efficient and practical organic synthesis methods are developed and reported daily in academia. However, the scale-up effect of organic synthesis makes scale-up quite challenging. Therefore, synthetic scale-up methods are crucially essential for the industrialization of organic reactions.

We hope that this topic will provide the recent advances and seminal guidelines for scale-up and better understand the critical points involved in kilogram-scale reactions compared with milligram-scale or gram-scale responses for promising their continuous development.

Areas to be covered in this research topic may include, but are not limited to

(1) Design synthetic methods that can be efficiently scaled up for kilogram-scale and sub-kilogram-scale. (e.g., what’s the difference between gram-scale and kilogram-scale reactions, how to control the scale-up process, etc.)

(2) Scale-up the asymmetric transformation (e.g., how to build a chiral center, how to keep the chirality, etc.)

(3) The use of kilogram-scale dangerous (flammable or explosive) or sensitive reagents (e.g., Butyl lithium, Grignard reagents, hyperoxides, etc.)

(4) Synthetic application of kilogram-sale organic reactions (e.g., bioactive compounds, organic materials, fine chemicals, etc.)

(5) Catalysis in large-scale organic reactions.

(6) Industrialization of organic reactions (e.g., organic reactions on a ton-scale)