Guest Editors
Tianshun Zhang
The Hormel Institute-University of Minnesota, USA
Dr. Tianshun Zhang received his PhD in Applied Chemistry in Bioscience from Kobe University, Japan. He currently works as a Senior Scientist at The Hormel Institute-University of Minnesota, USA. He focuses on identifying the mechanisms of cancer development or novel drug discovery for cancer prevention and treatment. He published his research in many prestigious journals including Cancer Research, Theragnostic, and EbioMedicine and is serving as guest editor for reputed journals.
Qiushi Wang
The Hormel Institute-University of Minnesota, USA
Dr. Qiushi Wang’s scientific interests naturally evolved into a focused attention on identifying the mechanism of cancer development or novel drug discovery for cancer prevention and treatment. As a senior scientist at The Hormel Institute of University of Minnesota, she has conducted multiple animal models in several projects focusing on lung, gastrointestinal, and skin cancers.
Collection Overview
Cancer is a chronic human disease, which affects millions of people worldwide, posing serious global concern. It is a leading cause of morbidity and mortality globally after cardiovascular diseases. Cancer has always been a research hotspot in the medical field. To understand the mechanism behind the disease, various animal models have been constructed. Several animal models have been generated by chemical/physical/viral induction, cell line-derived tumor xenograft (CDX), patient-derived xenotransplantation (PDX), and genetic engineering. Animal models are vital tools for understanding and studying the genetic functions and biology of human cancer. It has also been widely used in preclinical studies to assess the therapeutic potential of anticancer drugs and cancer chemo-preventive studies. Animal models enable scientist to understand the tumor biology in a complicated and dynamic physiological system. Remarkable advancement has been made in the generation of animal models. The use to application of new technologies and integration of clinical information from patients has aided in generation of sophisticated and personalized animal models. We hope to collect current animal models in cancer research as valuable preclinical tools, with the hope of successfully translating the basic knowledge into clinical application in cancer prevention and treatment.
