Practical Advances in Omics: Tips and Tricks of the Trade

TOPICAL COLLECTIONS

Guest Editor

Rihab Bouchareb

Icahn School of Medicine at Mount Sinai, New York

Dr. Rihab Bouchareb is an assistant professor in the Department of Medicine at the Icahn School of Medicine at Mount Sinai, New York (ISMMS). She graduated from the University of Strasbourg in France with a master's degree and a Ph.D. in cell and molecular biology. Dr. Bouchareb's Ph.D. focused on studying the molecular mechanism leading to atherosclerosis plaque rupture and platelet activation. After completing her postdoctoral training at the Quebec Heart and Lung Institute, Laval Hospital, Quebec, Canada, she joined the Mount Sinai Cardiovascular Research Center as a postdoctoral fellow and was subsequently promoted to instructor. She then moved to the Department of Nephrology as an assistant professor. Her research program currently investigates the effect of kidney disease on heart disease.

Collection Overview

Omics is an emerging field that plays a significant role in the discovery of novel pathways, proteins, microRNAs, and immune cell subsets. Robust omics data depends on the quality of sample preparation, sample size, and selection of appropriate controls. In the current collection, we aim to highlight the utility of cyTOF in discovering novel immune cell subsets. This special issue will cover many research areas, including proteomics, metabolomics, genomics, and transcriptomics. We will discuss preparation protocols, pitfalls, data interpretation, computational analysis, visualization, and applications. This Methods Collection aims to provide practical guidance to users new to omics research on understanding data

Articles

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Assessment of Mitochondrial Fission/Fusion Dynamics in Kidney Proximal Tubular Cells

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2025

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Vikky Awasthi¹, Sulaiman Qamar Sharief¹, Meriem Bkhache¹, Aasthika Das¹, Rihab Bouchareb¹

¹Lewis Katz Medical School at Temple University

Abstracts

Isolation of Nuclei from Frozen Human Heart Tissue for Single-Cell Multiomics analysis

Sarah Araten¹,

Anushka Jetly²,

Enning Wang³,

Erica Matsui⁴,

Nazia Hilal⁵,

Indu Sivankutty⁵,

Sangita Choudhury^*6

¹Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA,

²Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA and Harvard College, Cambridge, MA, USA,

³Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA and Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA,

⁴ Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA and Boston University, Boston, MA, USA,

⁵ Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA and Harvard Medical School, Boston, MA,

⁶ Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA and Harvard Medical School, Boston, MA and Broad Institute of MIT and Harvard, Cambridge, MA, USA

Harnessing Pan-Genomics and Epigenome Editing for Crop Improvement under Climate Change

Muhammad Talha Aslam^*1

¹Department of Agronomy, University of Agriculture Faisalabad, 38040, Pakistan.