Guest Editors
Mayanglambam Dhruba Singh
National Brain Research Centre, India
Dr. Mayanglambam Dhruba Singh is Scientist III at the National Brain Research Centre (NBRC), India. He received his PhD degree from the University of Delhi, India. He completed his post-doctoral studies at Pennsylvania State University and the University of Florida, USA. He worked with Drosophila models of disorders associated with 16p11.2 and 3q29 deletions and Alzheimer’s disease, respectively. His lab at NBRC is interested in understanding the molecular mechanisms of neurodevelopmental disorders and finding the molecular targets for neurodegenerative disorders. He works with Drosophila models of neurodegenerative disorders such as Alzheimer’s, Spinocerebellar ataxia-3, and Huntington’s disease.
Surajit Sarkar
University of Delhi, Department of Genetics
Dr. Surajit Sarkar is a Professor at the Department of Genetics, University of Delhi (South Campus), New Delhi, India. Dr. Sarkar received his PhD in Zoology from the Banaras Hindu University and completed his post-doctoral studies at the California Institute of Technology, Pasadena, California, USA. Prof. Sarkar’s research focuses on deciphering the cellular and molecular in-depths of human brain disorders and identifying and characterizing druggable targets/ drug molecules to develop novel therapeutic approaches. His group has identified several druggable targets against different human brain disorders by utilizing Drosophila disease models validated in mammalian systems. Prof. Sarkar is a life member of different academic bodies. He has served/serving as a reviewer of several reputed peer-reviewed international journals. He is a recipient of several awards, including the DST-Young Scientist, DST-BOYSCAST fellowship, DBT-Innovative Young Biotechnologists Award, and Excellence Award for In-Service Teachers of the University of Delhi.
Collection Overview
Traumatic Brain Injuries (TBI) are head injuries leading to compromised brain functioning with variable degrees of neuronal loss and cognitive impairment, as per the severity of the injury. It is frequently designated as a ‘silent epidemic’ as the number of TBI cases has exponentially increased in the past decades, causing over 50 million deaths worldwide every year. Moreover, brain injuries sustained during road accidents have been proposed to account for one of the major causes of death worldwide. External force(s) such as a crash, bump, or jolt, violent blow, penetration by a projectile such as a gunshot wound, blast waves, sports, and recreational activities that violate the cranium protection may cause TBI. Despite such surging statistics of TBI cases and associated mortalities or impairments, the unavailability of precise treatment for its management creates a devastating condition(s) for a patient and family.
Several model systems have been developed and tested occasionally to reproduce and study post-TBI conditions. Various approaches have been tried to induce different types of brain injuries in these organisms. Each model system has its limitations and strengths. This Methods Collection includes a variety of model organisms such as Rodents, Xenopus, zebrafish (Danio rerio), fruit fly (Drosophila melanogaster), and roundworms (Caenorhabditis elegans) which have been often utilized to investigate cellular and molecular aspects of different TBI types. The goal of this collection is to provide a clear overview of contemporary methods practiced to induce and investigate post-TBI conditions such as neuronal loss or neurodegeneration, altered cellular events, and intellectual/ behavioral impairments in these model organisms.
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