Platform Development and Biological Applications of Organ-on-a-Chip and Organoids

TOPICAL COLLECTIONS

Guest Editor

Ting Cao

The First Affiliated Hospital, Zhejiang University School of Medicine

Ting Cao is a researcher in the Department of Laboratory Medicine at The First Affiliated Hospital, Zhejiang University School of Medicine. She earned a Ph.D. in Analytical Chemistry from Peking University and completed her post-doctoral study at the University of Chinese Academy of Sciences. Ting Cao's research focuses on organ-on-chips, bacterial detection, and single-cell mRNA sequencing. Her laboratory's primary research goal is to develop organ-on-a-chip, focusing on drug screening and viral infection. Ting Cao has published over ten first-author/corresponding author publications, including Research, Proceedings of the National Academy of Sciences, Advanced Functional Materials, and Advanced Science.

Collection Overview

Organ-on-a-chip and organoids hold significant potential in disease modeling and drug testing as the next generation of experimental tools, replacing traditional cell culture techniques and animal testing. They can recapitulate the microarchitecture and microenvironment of human organs in vitro, eliminating species discrepancy and retaining physiological and pathological features at the organ level. Currently, they have been employed in various research fields, including disease studies, drug screening, preclinical trials, and translation. This Methods Collection introduces cutting-edge technologies with practical biological applications for an in-depth learning of organ-on-a-chip and organoids.

Articles

5:38

Generation of Apical-Out Intestinal Organoids and Assessment of Organoid Proliferation Rate Using EdU-Labeling

0 Views

•

Cited by 1

•

2025

•

Georg Csukovich^1,2, Maximilian Wagner¹, Kristina Schmidhofer^1,3, Barbara Pratscher¹, Iwan Anton Burgener¹

¹Small Animal Internal Medicine, Department for Small Animals and Horses, University of Veterinary Medicine, ²Cluster of Excellence Physics of Life, TU Dresden, ³Unit for Microbiology, Center for Pathobiology, Department for Biological Sciences and Pathobiology, University of Veterinary Medicine

Abstracts

An orthotopic mouse model of rectal cancer rapidly engrafts rectal cancer tumoroids to better study tumor biology and therapy

Chao Wu¹,

Joshua Smith^*1

¹Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA