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TOPICAL COLLECTIONS

Neurodegenerative Disorders

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Guest Editor

Vidyadhara D J, MSc, PhD

Vidyadhara D J, MSc, PhD

Yale University School of Medicine, Departments of Neurology & Neuroscience

Vidyadhara D J, PhD is a Postdoctoral Associate and the U.S. Dept. of Defense Early Investigator in the Departments of Neurology & Neuroscience, Yale University School of Medicine. He holds a PhD in Neurophysiology from National Institute of Mental Health & Neurosciences, Bangalore, India, along with a Master’s in Medical Physiology from Kasturba Medical College, Manipal, India. He started his research career studying ischemic brain injury as well as teaching Human Physiology in a medical school. He then shifted to neurodegeneration research during his doctoral studies. Vidyadhara has worked on different aspects of Parkinson’s disease (PD), namely, characterizing age-related glial changes in the human substantia nigra, the mechanisms for mice strain-dependent differential susceptibility to parkinsonian toxin MPTP, and autophagy modulating small molecules as a potential treatment strategy for PD. Currently, he is working on understanding the role of endolysosomal systems in the pathogenesis of PD. His studies focus on elucidating the mechanisms for auxilin (a clathrin uncoating protein) and glucocerebrosidase 1 (lysosomal enzyme) in causing both motor and non-motor dysfunctions of PD.

Collection Overview

Global health metrics implicate neurological disorders as the leading cause of disability and the second leading cause of death. Neurodegenerative disorders comprise a major part of those. Increase in life expectancy and population growth with increasing exposure to environmental risk factors pose a massive burden of neurodegenerative disorders in the coming years. Methodological advancements have aided in understanding the multimodal nature of these disorders, prion-like spreading of pathology, and even the involvement of peripheral systems in pathogenesis. In the scientific literature, these methods have been largely shadowed by compelling evidence research articles provide in enhancing our understanding of the disease mechanisms. Through this collection, we intend to bring these experiments to the forefront, and ease their access to the larger scientific community in a highly perceptible audiovisual format. We believe this would ultimately contribute to hastening the process of finding cures and preventions for a spectrum of neurodegenerative disorders.

There is a significant overlap in the methodologies that are employed to study the brain from various contexts. Neurodegenerative disorders have also broadened horizons with few of them showing overlapping motor, cognitive, and psychiatric impairments. Thus, this collection represents all the methods that could enhance our knowledge on neurodegeneration targeting various aspects of genetics, cytomolecular and biochemical pathways, circuits, and behavior. There is also scope for clinical studies involving surgical interventions and medical imaging, along with other diagnostic/prognostic methodologies. Innovations in the field of biomedical engineering, computation, and instrumentation aimed at providing relief to the patients are also encouraged.

Articles

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

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Cited by 26

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2014

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Cerebellar Regional Dissection for Molecular Analysis
8:51

Cerebellar Regional Dissection for Molecular Analysis

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Cited by 4

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2020

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Abstracts

Characterization of primary microglia from aged mice using single cell transcriptomics

Alexis Rickman1,

Addison Hilyard1,

Bradlee Heckmann*1,

Carolina Pena Martinez1

1USF Health Neuroscience Institute

A Novel MCAO Model with local intra-arterial drug delivery

Jordan Lee1

1University of Cambridge