Interactions between cells and molecules of the nervous and immune systems modulate organismal health in ways that are only beginning to be understood. Beyond their canonical role in tissue defense, neuroimmune interactions play a part in various physiological functions within the central and peripheral nervous systems, influencing development, maturation, and homeostasis. Emerging evidence further suggests that aberrant neuroimmune crosstalk is a common feature across a wide range of neuropathological conditions, including neurodevelopmental disorders, neuropsychiatric conditions, and neurodegeneration.
Innovative approaches for investigating neuroimmune mechanisms across model organisms, different cell types, tissues, organ systems, and varied neuropathological contexts have shed light on how immunological changes impact nervous system homeostasis and dysfunction. This collection aims to highlight recent methodologies that provide critical mechanistic insights into the molecular, cellular, and behavioral roles of neuroimmune interactions.