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TOPICAL COLLECTIONS

Current Methods for Exploring Neuroimmune Interactions in Health and Disease
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Nicole Scott-Hewitt

Nicole Scott-Hewitt

Duke University

Dr. Nicole Scott-Hewitt is an incoming Assistant Professor in the Cell Biology department at Duke University. She earned her PhD in Genetics from the University of Rochester under the mentorship of Dr. Mark Noble, where she investigated how lysosomal dysfunction and lipid dyshomeostasis contribute to neurodegeneration. As a postdoctoral fellow with Dr. Beth Stevens at Boston Children’s Hospital, her research focused on investigating how neuroimmune interactions shape the brain across development and aging. She uncovered a unique role of a secreted immune protein in critical intraneuronal processes; demonstrating that the microglial-derived complement protein C1q undergoes RNA-dependent liquid-liquid phase separation (LLPS), interacts with neuronal ribonucleoprotein (RNP) complexes in an age- and RNA-dependent manner, and impacts intraneuronal proteostasis in the adult brain. As an independent investigator she will continue to explore how neuroimmune and glial interactions have evolved unexpected downstream biological activities that impact brain function across aging and disease. 

Collection Overview

Interactions between cells and molecules of the nervous and immune systems modulate organismal health in ways that are only beginning to be understood. Beyond their canonical role in tissue defense, neuroimmune interactions play a part in various physiological functions within the central and peripheral nervous systems, influencing development, maturation, and homeostasis. Emerging evidence further suggests that aberrant neuroimmune crosstalk is a common feature across a wide range of neuropathological conditions, including neurodevelopmental disorders, neuropsychiatric conditions, and neurodegeneration. 

 

Innovative approaches for investigating neuroimmune mechanisms across model organisms, different cell types, tissues, organ systems, and varied neuropathological contexts have shed light on how immunological changes impact nervous system homeostasis and dysfunction. This collection aims to highlight recent methodologies that provide critical mechanistic insights into the molecular, cellular, and behavioral roles of neuroimmune interactions. 

 

Articles

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
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Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

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2025

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