Sepsis Models

TOPICAL COLLECTIONS

Sepsis Models

Guest Editor

Christian Lehmann

Dalhousie University

Dr. Christian Lehmann is Professor of Anesthesia, Pharmacology, Microbiology & Immunology and Physiology & Biophysics at Dalhousie University in Halifax, NS, Canada. He is also Staff Anesthesiologist in the Department of Anesthesia at Nova Scotia Health Authority in Halifax. Dr. Lehmann has 25 years of experience in experimental and clinical inflammation research. He established experimental intravital imaging laboratories in Berlin and Greifswald, Germany. His focus of research is the microcirculation, i.e. capillary blood flow, cell-cell-interactions, and endothelial pathology. He participated in diverse German and international clinical multicenter trials, e.g. in sepsis. He joined Dalhousie University in 2007 and currently supervises research in 3 laboratories with modern equipment to study the microcirculation under various conditions experimentally and clinically. He is the author of more than 150 original publications, 13 book chapters and almost 200 published abstracts. He is a member of the Dalhousie Inflammation Group (DIG), the Microcirculation Diagnostics and Applied Studies (MiDAS) research group and the Cystic Fibrosis Translational Research (CFTR) group. In 2009, Dr. Lehmann founded the RESIST (Research in the Endocannabinoid System in Inflammation, Sepsis and Trauma) group with Dr. Melanie Kelly and others at Dalhousie University.

Collection Overview

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Currently, there is no approved treatment available for the dysregulation of the immune system in human sepsis. Therefore, preclinical research in animal models of sepsis is inevitable for the discovery of novel therapies. Because of the multitude of animal studies in the field, detailed descriptions of the used methodologies are important to standardize and compare research and development activities. This methods collection will showcase the most important animal sepsis models, which can then be utilized for single- or multi-center preclinical studies.