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TOPICAL COLLECTIONS

Methodological Advances in Retinal Biology and Disease
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Guest Editor

Esmahan Durmaz

Esmahan Durmaz

Department of Genetic and Bioengineering, Alanya Alaaddin Keykubat University

Dr. Esmahan Durmaz is an assistant professor at Alanya Alaaddin Keykubat University. She received her PhD from Cardiff University, where her research focused on retinal diseases. Her work centers on the development of neuroprotective strategies for the glaucomatous retina, with the goal of preserving retinal ganglion cell survival and function.Dr. Durmaz’s research primarily investigates extracellular vesicle– and microRNA-based approaches as potential therapeutic tools for glaucoma and neurodegenerative disorders. She employs a range of experimental models, including in vitro retinal ganglion cell cultures, ex vivo retinal explants, and the in vivo microbead-induced glaucoma rat model, to study disease mechanisms and evaluate neuroprotective interventions. Through her work, Dr. Durmaz aims to advance translational strategies that may contribute to the development of novel treatments for glaucoma and related retinal neurodegenerative conditions.

Collection Overview

The retina is a highly specialised, multilayered neural tissue composed of distinct cell types, including retinal ganglion cells, photoreceptors, Müller glia, and the retinal pigment epithelium (RPE). It plays a critical role in converting light stimuli into neural signals that are transmitted to the brain. Consequently, structural or functional impairment of the retina can lead to irreversible visual dysfunction and blindness.


This collection brings together cutting-edge methodologies used in contemporary retinal research, spanning in silico, in vitro, ex vivo, and in vivo approaches. These include protein modeling and bioinformatics, neuroprotection assays, induced pluripotent stem cell (iPSC) differentiation into retinal cell types, animal models of retinal disease, and retinal tissue culture platforms for drug screening and therapeutic testing.


By integrating and standardising these diverse experimental strategies, the collection aims to improve reproducibility, enable robust cross-study comparisons, and accelerate the rational design of next-generation approaches for understanding retinal disease mechanisms and developing effective therapies.