Guest Editors
Gabriela Gutierrez-Reyes
Universidad Nacional Autónoma de México, Hospital General de México “Dr. Eduardo Liceaga," Laboratorio de Hígado, Páncreas y Motilidad, Unidad de Medicina Experimental, Facultad de Medicina
Gabriela Gutierrez-Reyes received her Bachelor's degree in Biology from the National University of Mexico (UNAM), and her MSc (Experimental Biology) and PhD degrees from the Metropolitan Autonomous University (UAM, Mexico). She is a Full Professor and Head of the Laboratory of Liver, Pancreas and Intestinal Motility (HIPAM Lab) at the Unit of Research in Experimental Medicine, School of Medicine (UNAM). Dr. Gutierrez-Reyes is a member of National Research System (Mexico) and has authored over 50 scientific publications. Her research lines include inflammation, tissue damage/regeneration, and the mechanisms involved in gastrointestinal and liver diseases.
Carolina Guzmán
Universidad Nacional Autónoma de México, Hospital General de México “Dr. Eduardo Liceaga," Laboratorio de Hígado, Páncreas y Motilidad, Unidad de Medicina Experimental, Facultad de Medicina
Carolina Guzman received her Bachelor's degree in Chemistry and her PhD in Biomedicine from the National University of Mexico (UNAM). She was a post-doctoral fellow at the Institute of Biomedical Research (UNAM). She was awarded the L’Oreal-UNESCO-AMC-For Women in Science prize for young female scientists in Mexico. She is a full-time researcher at Hospital General de México, a part-time professor at the School of Chemistry, UNAM. and a member of the National Research System (Mexico). Her research interests are the diagnosis and physiopathology of chronic liver diseases, endocrine interactions. and toxicity. She has authored more than 20 original research papers that have received >600 citations.
Collection Overview
Chronic liver disease leading to cirrhosis, liver failure and hepatocellular carcinoma represent an important burden on health care systems worldwide, accounting for approximately 2 million deaths every year. The most common cause of liver disease is metabolic associated fatty liver disease (previously known as NAFLD), a hepatic condition associated with obesity, type 2 diabetes, and dyslipidemia. Other highly prevalent causes of cirrhosis are viral hepatitis (particularly hepatitis B and C) and alcoholic liver disease.
Most people affected by liver diseases, regardless of the etiology, are unaware of their condition, mainly because symptoms become evident at very advanced stages when cirrhosis is irreversible. At that specific stage, liver transplantation is the only effective option for the treatment of decompensated cirrhosis; however, donor tissue is extremely scarce.
Although diagnostic and therapeutic strategies have been developed for liver diseases, they have shown several disadvantages, including low sensitivity and specificity, difficulties in implementation, availability restricted by geography or economic means, and insufficient efficacy. Therefore, there is still a need to improve timely diagnosis, identification of the degree of fibrosis, and the development of therapeutic options from pharmacology and beyond.
Experimental models of liver disease are an excellent option to identify diagnostic and therapeutic targets, providing valuable evidence and helping to improve hepatic health in a translational fashion. This collection is intended to include translational models for the study of liver disease, helping scientists to identify and develop strategies for diagnosis and treatment.
Articles
Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy
0 Views
•
Cited by 2
•
2021
•
Benjamín León-Mancilla1,2, Moisés Martínez-Castillo1, Zaira Medina-Avila1, Armando Pérez-Torres3, Jorge Garcia-Loya2, Ana Alfaro-Cruz4, Cristina Piña-Barba5, Gabriela Gutierrez-Reyes1
1Liver, Pancreas and Motility Laboratory; Unit of Experimental Medicine; School of Medicine, Universidad Nacional Autónoma de Mexico (UNAM), 2Department of Surgery, School of Medicine, Universidad Nacional Autónoma de México (UNAM), 3Department of Cells and Tissue Biology, School of Medicine, Universidad Nacional Autónoma de México (UNAM), 4Department of Pathology, Hospital General de Mexico, 5Materials Research Institute, Universidad Nacional Autónoma de México (UNAM)
A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
0 Views
•
Cited by 2
•
2022
•
Khanit Sa-ngiamsuntorn1, Piyanoot Thongsri2, Yongyut Pewkliang2, Suparerk Borwornpinyo3,4, Adisak Wongkajornsilp5
1Department of Biochemistry, Faculty of Pharmacy, Mahidol University, 2Program in Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 3Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, 4Department of Biotechnology, Faculty of Science, Mahidol University, 5Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University
Abstracts
THE NOVEL USE OF R1T1 ROBOT AND APSCERR EQUIPMENT AS AID IN THE PREOPERATIVE PROCESS OF HEPATIC TRANSPLANT: A GREEN INDOCININE EXPERIMENT IN WISTAR RATS
Antonio Henrique Dianin*1
1State University of Campinas - Unicamp