Established and Innovative Methods to Study Atherosclerosis

TOPICAL COLLECTIONS

Guest Editor

Abdul Waheed Khan

Monash University, Central Clinical School, Department of Diabetes

Dr. Abdul Waheed Khan is a National Heart Foundation funded Research Fellow within the Department of Diabetes, Monash University, Australia. He is a current member of the executive of the Australian Atherosclerosis Society. He is also the founder and first president of the “Society for Research in Medicine (SRMed). SRMed is a society run by early to mid-career medical researchers that aims to disseminate research knowledge firsthand directly from researchers to the general public in simple language. Dr. Khan graduated with a master’s degree from the Baker Heart and Diabetes Research Institute in 2009 and worked on the role of B2 B cells in atherosclerosis. He undertook his PhD on the role of MeCP2 in the silencing of the Norepinephrine transporter gene in Postural Tachycardia Syndrome (POTS). After his PhD, he was awarded a scholarship to conduct postdoctoral training in the Karolinska Institute, Sweden. His postdoctoral studies identified critical epigenetic changes associated with microvascular function in elderly with increased cardiovascular risk. He was also awarded highly competitive early career research grants during his postdoctoral training. In his current position, Dr. Khan aims to study the epigenomics of diabetes associated atherosclerosis. His work on the epigenetic mechanisms in diabetes associated atherosclerosis promises to be an exciting new area in cardiovascular research.

Collection Overview

Cardiovascular disease (CVD) is the leading cause of death globally with the profound economic impact on the society. Atherosclerosis, the lipid-laden lesion development in the vascular wall, is the primary cause of CVD. The atherosclerotic lesion progress from fatty streak to vulnerable plaque that on rupture, cause thrombosis and arterial blockage. This interrupted blood supply to vital organs such as heart and brain leads to serious life-threatening conditions such as heart attack and stroke. Several risk factors including blood flow-mediated hemodynamic forces, diabetes, obesity, smoking and alcohol consumption have been identified in the pathological plaque development. Use of the established methods in pre-clinical and clinical studies have advanced our understanding of the complex process of plaque development including endothelial dysfunction, turbulent blood flow, immune cell infiltration, into intima and oligoclonal expansion of vascular smooth muscle cells. Recent advances in state-of-the-art technologies across multiple disciplines including medical imaging, animal models, genomics, epigenomics, and biomechanics have the potential to advance our efforts in identifying novel therapeutic targets for atherosclerosis. This collection of methods aims not only to assemble established methods but also to provide innovative cutting-edge methods in atherosclerosis research.

Articles

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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

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Cited by 4

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2022

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Harry J. Carpenter¹, Mergen H. Ghayesh¹, Anthony C. Zander¹, Juanita L. Ottaway², Giuseppe Di Giovanni³, Stephen J. Nicholls⁴, Peter J. Psaltis^3,5,6

¹School of Mechanical Engineering, University of Adelaide, ²South Australian Health and Medical Research Institute (SAHMRI), ³Vascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), ⁴Monash Cardiovascular Research Centre, ⁵Adelaide Medical School, University of Adelaide, ⁶Department of Cardiology, Central Adelaide Local Health Network

Abstracts

cardio-ankle vascular index (CAVI) and the mathematical correction form (CAVI0) for evaluation of atherosclerosis

Javad Alizargar^*1,

Elaheh Alizargar²

¹Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences,

²Department of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan

Isolation and Primary Culture of Murine Aortic Cells for Atherosclerosis Research

Carmel Assa¹,

Rulin Zhang¹,

Jingshu Chen¹,

Mark W Feinberg^*1

¹Department of Medicine, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School

Static Cell Adhesion Assays for investigating leukocyte-endothelial interactions in vitro

Arpeeta Sharma^*1

¹Baker Heart and Diabetes Institute