Affiliation: Dana-Farber Cancer Institute and Harvard Medical School

Shourya S. Roy Burman is a research fellow at Dana-Farber Cancer Institute and Harvard Medical School. As a member of Dr. Eric Fischer’s group, he designs new systems for targeted protein degradation using computational modeling and design, biophysical and biochemical techniques, and flow cytometry. He is the recipient of the Cancer Research Institute Irvington Postdoctoral Fellowship for his research on the use of compound-mediated protein degradation in cell therapies.

Dr. Roy Burman obtained his PhD in Chemical and Biomolecular Engineering from Jeffrey Gray’s group at the Johns Hopkins University, where he developed algorithms for protein modeling as a part of the Rosetta Macromolecular Modeling Suite. Prior to that, he received his bachelor’s degree in Bioengineering from the Indian Institute of Technology Kanpur.

Dr. Roy Burman’s research identified that the position of ubiquitinatable lysines on a target protein in a ternary complex with the E3 ubiquitin ligase is the single most important intrinsic feature that determines its tractability to targeted degradation approaches. His protein docking algorithms have been widely used to model degrader-induced complexes and guide the design of new molecules.