Affiliation: National Cancer Institute, NIH

Yilun Sun’s research interest is to comprehensively characterize molecular and cellular mechanisms for repairing topoisomerase inhibitor- and PARP inhibitor-mediated DNA damage. He delineated several post-translational modification-regulated mechanisms that resolve drug-induced topoisomerase DNA-protein crosslinks including pathways regulated by ubiquitylation, SUMOylation, neddylation and ADP-ribosylation.