Mitochondrial morphological and functional abnormalities play a crucial role in various diseases, including high altitude hypoxia-induced brain damage, cardiovascular and cerebrovascular disorders, complications related to diabetes, rheumatoid arthritis, allergic rhinitis, and cancer, among others. The therapeutic efficacy of ethnomedicine in addressing these diseases characterized by mitochondrial injury is noteworthy.

We invite and encourage submissions of manuscripts that employ diverse methodologies to investigate the protective effects of ethnomedicine on mitochondrial health. A wide array of techniques is used in the screening and validating mitochondrial morphology, function, and potential targets affected by ethnomedicine. These techniques include laser confocal imaging, high-content imaging, the Seahorse cell energy metabolism analyzer, surface plasmon resonance (SPR), microscale thermophoresis (MST), bio-layer interferometry (BLI), cellular thermal shift assay (CETSA), differential scanning fluorimetry (DSF), and patch clamp technology.

This Methods Collection comprehensively encompasses studies using animal models, organoids, and cellular models to investigate mitochondrial diseases.

Qipeng Zhao