Affiliation: Hackensack Meridian Health Center of Discovery and Innovation

The goal of my research program is to model and understand the genetic progression of colorectal cancers from initiation through metastasis. My lab focuses on the critical tumor suppressor SMAD4/Tgfβ pathway, which is mutated in 60% of all cancers, and is often correlated with poorer prognosis in colon cancer patients. I have established genetically engineered mouse models and organoid systems to systematically assess how tumors develop and understand the critical drivers of cancer.