Affiliation: Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Dr. Chang Yuan, PhD, is a researcher at Fuwai Hospital, Chinese Academy of Medical Sciences, specializing in the mechanisms of heart transplant rejection. His work aims to improve long-term heart transplant outcomes through pre-transplant immune tolerance induction, post-transplant graft function preservation, and the prevention of late acute rejection. His research focuses on developing novel immunosuppressive agents, investigating primary graft dysfunction mechanisms, and regulating innate immune activation in transplant rejection. 

Utilizing advanced techniques such as single-cell sequencing, transcriptomic analysis, and mouse heterotopic heart transplantation models, Dr. Yuan explores key immune pathways to optimize immunosuppressive strategies for heart transplantation. His research has been published in leading journals such as Circulation and Science Translational Medicine.