Affiliation: Yale School of Medicine

Dr. Langston is an assistant professor in the Department of Pathology at Yale School of Medicine and a member of the Yale Center for Research on Aging (Y-Age). Work from his postdoctoral fellowship in the Mathis-Benoist laboratory at Harvard Medical School mapped the dynamics of physiological inflammatory responses to endurance exercise in skeletal muscles and revealed that appropriate control of such inflammation by regulatory T cells is required for the muscle-specific and organism-level metabolic adaptations and improved performance typical of training. Dr. Langston also discovered that physiological and pathological inflammation in muscle is induced, in part, by a mechanosensitive subtype of mesenchymal stromal cells.



The Langston laboratory is further defining the cellular and molecular features of exercise-induced inflammatory responses in youth and during aging with an emphasis on elucidating how non-parenchymal cells sense exercise and regulate its benefits. An ultimate goal of this work is to design exercise-inspired interventions to combat modern afflictions associated with chronic inflammation, improve regeneration and performance after injury, reduce the pathology of musculoskeletal diseases, and combat age-related frailty (i.e., increase healthspan).