Affiliation: Buck Institute for Research on Aging

Dr. Basisty is a postdoctoral fellow at the Buck Institute for Research on Aging. He received his PhD in Pathology and BS in Biochemistry from the University of Washington. Dr. Basisty develops novel and specialized proteomic approaches to understand aging processes and age-related diseases, including the application of data-independent acquisition (DIA) or SWATH workflows to identify and quantify PTMs and secretomes, development of pipelines to comprehensively assess protein turnover rates, and cell-surface proteomics (surfaceomics).  A major aim of his current work is to discover biomarkers of cellular senescence and develop translationally relevant approaches to study senescent cells in people. 

Dr. Basisty has been recognized for his work investigating the role of protein turnover in mammalian aging and longevity using novel combinations of metabolic labeling, LC-MS/MS, and software tools. He has applied these proteomic approaches to understand changes to the composition and turnover of the mouse proteome during aging and in mouse models of longevity, including calorie restriction (CR) and rapamycin treatment. These works have resulted in two “Aging Cell Best Paper Prizes”, in 2014 and 2016. He was also lead author in a study examining protein turnover rates in long-lived mice overexpressing mitochondria-targeted catalase (mCAT), which demonstrates that the mCAT proteome exhibits “reverse antagonistic pleiotropy” and suggests that reactive oxygen species may exhibit true antagonistic pleiotropy. For this work, he received The Joseph A. Pignolo, Sr. Award in Aging Research 2017, recognized as the “year’s most outstanding contribution to basic aging research”.