Electrophysiological Investigations
Electrophysiological Investigations - Related Videos
09:09
Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
0 Views •
Cited by 3 •
2019
Here, we present protocols for the preparation of acute brain slices containing the lateral geniculate nucleus and the electrophysiological investigation of retinogeniculate and corticogeniculate synapses function. This protocol provides an efficient way to study synapses with the high-release and low-release probability in the same acute brain slices.
10:46
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
0 Views •
Cited by 4 •
2015
Radiation exposure is an underestimated risk in complex ablation procedures. Here, we describe a protocol to significantly decrease fluoroscopy time and dosage for both the patient and the lab staff by using a novel non-fluoroscopic catheter visualization system.
05:41
Applying Microfluidics to Electrophysiology
0 Views •
Cited by 1 •
2007
Microfluidics can be integrated with standard electrophysiology techniques to allow new experimental modalities. Specifically, the motivation for the ...
14:27
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
0 Views •
Cited by 11 •
2019
We used recording and stimulation electrodes in longitudinal hippocampal brain slices and longitudinally positioned recording and stimulation electrodes in the dorsal hippocampus in vivo to evoke extracellular postsynaptic potentials and demonstrate long-term synaptic plasticity along the longitudinal interlamellar CA1.
07:14
Healthy Brain-pituitary Slices for Electrophysiological Investigations of Pituitary Cells in Teleost Fish
0 Views •
Cited by 8 •
2018
The article describes an optimized protocol for making viable brain-pituitary tissue slices, using the teleost fish medaka (Oryzias latipes), followed by electrophysiological recordings of pituitary cells using the patch-clamp technique with the perforated patch configuration.
FAQs
Electrodes or electronic interfaces contact the biological system and detect voltage changes or ionic currents generated by living cells and tissues. These signals vary over time, so the recording preserves their temporal behavior rather than treating electrical activity as a single fixed value. This makes it possible to examine communication and functional responses in biological models.
Amplification increases the measurable strength of detected electrical activity, while filtering helps shape the recorded signal for analysis under controlled conditions. Together, these processing steps support clearer time-dependent recordings from cells, tissues, or organs. The resulting data can make functional patterns and abnormalities easier to evaluate when developing bioengineering systems.
Time-dependent electrical recordings can indicate how biological systems communicate and function, including whether activity changes under a controlled condition. In bioengineering, this information helps characterize neurons, cardiac tissue, skeletal muscle, and engineered biological models. Differences in the recorded signals may reveal functional abnormalities or responses that are relevant to device and interface development.
A typical investigation places electrodes or an electronic interface with the selected cells, tissue, organ, or engineered model, then records voltage changes or ionic currents under controlled conditions. The signals are amplified, filtered, and stored as time-dependent measurements. Researchers can then assess functional behavior, responses, or abnormalities in the biological system being studied.
The approach can characterize several systems, including neurons, cardiac tissue, skeletal muscle, and engineered biological models. This breadth allows investigators to examine electrical function across different biological contexts rather than restricting measurements to one cell type or organ. In bioengineering, such comparisons support the evaluation of biological responses and the design of compatible electronic technologies.
Electrophysiological investigations provide functional measurements that guide the development of biosensors, neural interfaces, and therapeutic devices. They can also assess how cells or tissues respond within engineered biological models. By connecting measured biological activity with electronic systems, the method helps bioengineers evaluate performance, identify functional abnormalities, and refine technologies intended to interact with living systems.