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08:30
X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
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Cited by 2 •
2011
We are developing a dynamic adaptive exposure technique using our scanning beam digital X-ray system. Rather than exposing an object uniformly, the exposure is adapted depending on the opacity of the object. Here we show an experiment on an anthropomorphic phantom that resulted in a dose saving of 30%.
11:53
Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
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Cited by 6 •
2017
We present a novel method that uses photo-responsive block copolymers for more efficient spatiotemporal control of gene silencing with no detectable off-target effects. Additionally, changes in gene expression can be predicted using straightforward siRNA release assays and simple kinetic modeling.
08:55
COVID-19 / Coronavirus Outbreak: Hemodynamic monitoring with PiCCO artery
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2020
During pandemics, medical staff become a key resource in treating and managing patients with these infectious diseases. To achieve the best medical care, relevant techniques and procedures must be taught to medical staff which minimize the risk of work-related transmission of infection. When carrying out hemodynamic monitoring in cardiovascularly unstable patients, it is possible to utilize a Pulse Contour Cardiac Output (PiCCO) catheter. This system utilizes a thermodilution method to analyze...
07:39
Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures
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Cited by 5 •
2013
We report a method to isolate naïve multipotent skin-derived precursor (SKP) cells from primary human fibroblast cultures. We show that these SKPs derived from fibroblast cultures share similar stem cell properties to the ones derived directly from human skin biopsies. These cells express the neural crest marker, nestin, in addition to the multipotent markers such as OCT4 and Nanog.
06:56
COVID-19 / Coronavirus Outbreak: How to perform complete prone positioning in COVID-Patients
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2020
In pandemic times, medical staff is becoming a key resource in fighting the infection. To achieve the best medical care, relevant techniques and procedures have to be taught to medical staff while reducing the risk of infection. COVID-19 patients often develop an acute respiratory distress syndrome with respiratory failure. Prone positioning is established as a core component of management in COVID-19 patients, to enable ventilation of a greater lung area and thereby improve gas exchange. This...
FAQs
System pressure can increase the ring’s contact with the surrounding sealing surfaces. This pressure-assisted contact supports the initial seal created by elastic deformation, helping close microscopic gaps between joined components. The effect matters in bioengineering equipment because maintaining contact helps limit fluid or gas leakage during operation of pumps, bioreactors, and other containment systems.
The machined groove positions the ring between the mating components and provides the space needed for controlled compression. When the components are joined, the elastomer deforms within this arrangement and fills microscopic surface gaps. Groove design therefore connects installation geometry with sealing reliability, particularly where assemblies must contain sterile fluids or gases.
Chemical compatibility, sterilization conditions, temperature, pressure, and repeated compression all influence performance. A material that tolerates one operating environment may not remain reliable under another combination of chemical exposure, heat, pressure, or reuse. Considering these variables together helps preserve elastic sealing behavior and reduces the risk of leakage or contamination in bioengineering systems.
Installation centers on placing the ring in a machined groove and then joining the mating components so the elastomer becomes compressed. The compression allows the ring to conform to microscopic gaps at the interface, while operating pressure may strengthen contact with the sealing surfaces. This sequence creates the containment function without changing the joined components themselves.
Bioengineering applications include pumps, bioreactors, microfluidic devices, and sterile fluid-handling assemblies. In these systems, the seal supports containment by limiting the escape of fluids or gases and reducing opportunities for contamination. Its value is therefore tied not only to mechanical assembly but also to maintaining controlled conditions during fluid processing and handling.
Selection requires matching the ring’s material and dimensions to the system’s chemical compatibility, sterilization conditions, temperature, pressure, and expected compression history. These factors determine whether the elastomer can maintain contact and deformation over use. Evaluating them before assembly helps researchers choose a seal suited to reliable containment in pumps, bioreactors, or microfluidic equipment.