Alveolates

Alveolates are a major clade of eukaryotic organisms defined by membrane-bound sacs called cortical alveoli beneath the plasma membrane, making them important for understanding eukaryotic diversity and evolution. Many alveolates use these flattened sacs to support the cell cortex, regulate shape and membrane interactions, or contribute to specialized structures involved in movement and host invasion. The group includes ciliates, dinoflagellates, and apicomplexans, whose varied lifestyles range from free-living feeding and photosynthesis to parasitism. Studying alveolates helps explain aquatic food webs, harmful algal blooms, symbiosis, and diseases such as malaria, while comparative genomics reveals how complex cellular traits evolved.

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Research

JoVE Journal - Cancer Research

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

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2021

Here, we present an easy-to-use co-culture assay to analyze glioblastoma (GBM) migration on patterned neurons. We developed a macro in FiJi software for easy quantification of GBM cell migration on neurons, and observed that neurons modify GBM cell invasive capacity.

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