Prostate Gland
Prostate Gland - Related Videos
03:24
Extracting Prostate from Mouse Urogenital System: A Technique to Separate Prostate Gland from Other Urinary and Genital System Organs in Male Mouse
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2023
In this video, we describe the procedure for the dissection of the urogenital system or UGS from a male mouse model. This UGS is further dissected ex vivo to isolate the prostate gland and study its role in prostate cancer development.
02:34
Individual Lobe Extraction from Prostate: A Technique to Harvest Individual Prostate Lobes from Mouse Prostate
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2023
This video describes a technique to harvest individual lobes from the prostate gland of a mouse model. Individual lobes can then be used for histological analysis and cancer research.
05:07
Intra-prostatic Injection of Cancer Cells: A Technique to Deliver Cancer Cells for Establishing Orthotopic Prostate Cancer Mouse Model
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2023
In this video, we demonstrate the procedure for administering intra-prostatic injection of prostate cancer cells into a mouse model. Orthotopic murine models can be used to study the disease origin and response to treatment therapies in a non-invasive and clinically relevant environment.
08:49
Murine Prostate Micro-dissection and Surgical Castration
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Cited by 23 •
2016
This manuscript describes the protocols for prostate micro-dissection and surgical castration in the laboratory mouse. We also depict representative results produced by these protocols. Finally, we discuss the advantages and utilization of these protocols.
04:16
Prostate Organoid Assay: A Matrix Gel Ring-based Ex Vivo Culture Technique to Study the Differentiation Capacity of Prostate Epithelial Cells
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2023
In this video, we demonstrate the culturing of isolated mouse prostate epithelial cells using a matrix gel-ring based culture technique. This approach can provide complementary information about the differentiation capacity of prostate epithelial cells to form 3D glandular structures in response to genetic or pharmacological manipulation.
FAQs
The glandular cells supply prostate fluid, whereas surrounding smooth muscle provides the mechanical force that contracts during ejaculation. These functions complement one another: secretion contributes to the fluid mixture containing sperm and secretions from other reproductive glands, while contraction helps mix and propel that material through the urethra. Studying both components clarifies how prostate tissue supports reproductive function.
Because the prostate surrounds the urethra below the bladder, changes within the gland can influence the passage through which urine exits the bladder. This anatomical relationship connects prostate disorders with urinary effects. In biology and clinical research, examining the gland therefore requires attention not only to reproductive function but also to urinary physiology and the consequences of altered surrounding tissue.
Inflammation, benign prostatic enlargement, and cancer represent distinct changes that can disrupt normal prostate structure or activity. The overview identifies each as a condition capable of affecting urination and, in some cases, fertility. Comparing these conditions with normal anatomy and secretion helps researchers relate cellular or tissue changes to reproductive and urinary outcomes without treating all prostate abnormalities as equivalent.
Prostate-specific antigen, or PSA, is an important marker in clinical research and diagnosis involving the prostate. Its relevance comes from its association with prostate-focused assessment, alongside examination of gland anatomy and secretory activity. In a broader biological context, PSA illustrates how a prostate-associated measurement can complement structural and functional study when researchers investigate changes in the gland.
Research commonly considers three connected aspects: prostate anatomy, secretory activity, and effects on urinary physiology. Anatomy establishes how the gland relates to the bladder and urethra, secretory studies address glandular contributions to semen, and urinary assessment considers functional consequences of change. Together, these perspectives support investigation of normal male reproductive biology as well as disease-related alterations.
Prostate function links these fields through its contribution to semen and its close anatomical relationship with the urinary tract. Secretory and contractile activity matter when studying semen formation and propulsion, while the gland’s position makes urinary effects relevant when its condition changes. Considering both outcomes gives a more complete view of prostate biology than examining reproduction or urination alone.