Prosthetic Groups
Prosthetic Groups - Related Videos
06:58
A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
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Cited by 34 •
2015
As prosthetic development moves towards the goal of natural control, harnessing amputees’ inherent ability to learn new motor skills may enable proficiency. This manuscript describes a structured rehabilitation protocol, which includes imitation, repetition, and reinforcement learning strategies, for improved multifunctional prosthetic control.
08:04
Customizing a Cryolite Glass Prosthetic Eye
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Cited by 12 •
2019
This manuscript shows each step of customizing a cryolite glass prosthetic eye including some major advantages of the use of cryolite glass for manufacturing an eye prosthesis compared to poly(methyl methacrylate). In addition, this manuscript gives ophthalmologists better insight into the ocularistic care that could improve interprofessional collaboration.
07:23
An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
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Cited by 5 •
2016
A detailed procedure for the synthesis of a 125I-labeled azide and the radiolabeling of dibenzocyclooctyne (DBCO)-group-conjugated, 13-nm-sized gold nanoparticles using a copper-free click reaction is described.
11:16
Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis
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Cited by 15 •
2014
Neural-machine interfaces (NMI) have been developed to identify the user's locomotion mode. These NMIs are potentially useful for neural control of powered artificial legs, but have not been fully demonstrated. This paper presented (1) our designed engineering platform for easy implementation and development of neural control for powered lower limb prostheses and (2) an experimental setup and protocol in a laboratory environment to evaluate neurally-controlled artificial legs on patients with...
08:08
Oscillation and Reaction Board Techniques for Estimating Inertial Properties of a Below-knee Prosthesis
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Cited by 35 •
2014
Body segmental inertial properties are required for inverse dynamics modeling. Using an oscillation and reaction board technique, inertial properties of below-knee prostheses were measured. Using direct measures of prosthesis inertia in the inverse dynamics model of the prosthetic leg resulted in lower magnitudes of resultant joint forces and moments.
FAQs
They supply chemical capabilities that the protein portion cannot provide alone. Depending on the group, this contribution may support a chemical reaction, transfer electrons, absorb light, or participate in binding. The protein positions and holds the group, while the group contributes directly to the activity, allowing the complete protein system to perform its biological role.
The key distinction is how strongly the non-protein component associates with its protein. Prosthetic groups remain tightly, often permanently, bound, whereas loosely associated cofactors do not have the same persistent attachment. This difference helps explain why some proteins depend on an integral component throughout their activity rather than interacting with a temporary helper.
Heme supports functions such as oxygen-related activity in hemoglobin and electron transfer in cytochromes. Flavin groups participate in redox enzymes, where electron-transfer chemistry is important. Biotin serves carboxylases, enzymes associated with carboxylation reactions. These examples show that the chemical identity of the group determines the capability it adds to its protein.
Because these components are essential to protein activity, changes affecting them can alter the reactions, electron transfer, light absorption, or binding events that the protein performs. The consequences may extend beyond one protein when it participates in metabolism or energy capture. Studying such changes therefore connects molecular alterations with disrupted cellular function and disease.
Researchers can examine which tightly bound components support particular protein activities and then relate those functions to pathway behavior. Heme and flavin groups help illustrate how proteins transfer electrons, while biotin illustrates participation in carboxylase activity. This perspective clarifies how metabolic pathways carry out chemical transformations and capture or transfer energy.
Analyzing the protein alone may not explain its biological activity, because the essential chemical contribution can come from its bound non-protein component. Considering both parts reveals how enzymes and transport proteins carry out reactions or binding events. It also provides a framework for connecting molecular structure with energy transfer, metabolism, cellular function, and disease.