Thermoregulation

Thermoregulation is the biological process by which organisms maintain body temperature within a functional range despite changes in internal heat production or the external environment. In animals, sensory receptors detect temperature shifts, while the hypothalamus and other control systems coordinate responses such as sweating, shivering, changes in blood flow, altered metabolic activity, and behavioral adjustments; these responses rely largely on negative feedback. Thermoregulation supports enzyme activity, cellular function, and survival, but its mechanisms differ among ectotherms and endotherms. Studying this process helps explain adaptation, responses to exercise and environmental stress, and the biological consequences of fever, hypothermia, and climate change.

Thermoregulation - Related Videos

Education

JoVE Core - Anatomy and Physiology

Thermoregulation

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2024

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...

Research

JoVE Journal - Bioengineering

Standardized Protocol For Monitoring Muscle Fatigue and Biomechanics In Amateur Cyclists Using Infrared Thermography

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2026

Cycling biomechanics relies on efficient muscle activation and core stabilization. Infrared thermography (IRT) offers non-invasive monitoring of muscle fatigue. This protocol establishes a standardized methodology for integrating IRT into biomechanical analysis, aiming to optimize performance and prevent injury in amateur cyclists through precise physiological monitoring.

Research

JoVE Journal - Cancer Research
Free Sample

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

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Cited by 1 •

2026

The stereotactic intracranial injection technique enables precise and localized implantation of tumor cells into the mouse cortex, making it a powerful model for studying metastatic colonization of the brain.

Research

JoVE Journal - Medicine
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The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

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Cited by 18 •

2014

This article describes bronchoscopic techniques in the bovine lung under experimental conditions, i.e. bronchoscopically guided inoculation, bronchoalveolar lavage, bronchial brushing, and transbronchial lung biopsy.

Basic Care Procedures

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2016

Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN Mice and rats account for a large proportion of the animals used in biomedical research. Ensuring their welfare is both an ethical responsibility and essential for scientific validity. There are general procedures that apply to the majority of these mice and rats, but some of the animals, such as the immunocompromised ones, require additional steps to be taken to sustain them for...

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