Renal Replacement Therapy
Renal Replacement Therapy - Related Videos
01:30
Continuous Renal Replacement Therapy
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2025
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
01:26
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
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2025
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Cited by 23 •
2017
Implementation of an orthotopic model of renal cell carcinoma in immunocompetent mice affords the investigator a clinically-relevant system defined by the presence of a primary renal tumor and lung metastases in the same animal. This system can be used to preclinically test a variety of treatments in vivo.
09:34
Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
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Cited by 10 •
2017
Age-related diseases are associated with multiple defects in components of the cytoplasm. Here, we present a protocol to prepare plasma membrane vesicles from bone marrow mesenchymal stem cells. This technique could potentially be used as a means of cytoplasm replacement therapy to ameliorate or even reverse age-associated phenotypes.
06:38
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Cited by 14 •
2016
Early stage hemodynamic dysfunction is critical to the development of kidney disease. Yet, detection methodologies are limited. Recent advances in sonography provide a noninvasive, accurate option for early detection of kidney injury. This study outlines a step-by-step, sonographic methodology for detecting kidney dysfunction using a drug-induced nephrotoxicity rat model.
FAQs
These mechanisms address different clearance needs. Diffusion moves solutes across a semipermeable membrane, while convection carries solutes along with fluid movement. Ultrafiltration removes excess water by driving fluid across the membrane. Together, they allow treatment to target waste removal, fluid overload, and disturbances in electrolyte or acid–base balance rather than relying on a single clearance process.
The semipermeable membrane provides a controlled interface between blood and dialysate, allowing selected fluid and solute exchanges while supporting removal of unwanted substances. Its role enables diffusion and convection for solute clearance and ultrafiltration for water removal. This membrane-based design gives clinicians a means to address several consequences of inadequate kidney function during treatment.
Renal replacement therapy includes hemodialysis, peritoneal dialysis, and continuous kidney replacement therapy. These modalities represent different treatment approaches within the same broader therapeutic framework. Continuous kidney replacement therapy is specifically identified for critically ill patients, whereas the overall group can support either severe acute kidney injury or end-stage kidney disease, depending on the clinical setting.
In severe acute kidney injury, RRT can temporarily support patients while clinicians manage the resulting fluid, electrolyte, and metabolic disturbances. In end-stage kidney disease, it can serve as longer-term therapy because kidney function is no longer adequate for essential regulation. Thus, the same treatment category may provide short-term stabilization or ongoing replacement of kidney function.
RRT can stabilize critically ill patients by addressing excess fluid, abnormal electrolytes, and acid–base or other metabolic disturbances associated with inadequate kidney function. Its value extends beyond waste clearance: treatment supports physiologic control while clinicians continue managing the underlying acute illness. Continuous kidney replacement therapy is one modality identified in this critical-care context.
For patients whose kidneys cannot sustain essential regulatory functions, RRT may provide ongoing support while transplantation is pursued. In this role, it bridges the period between severe kidney failure and receipt of a transplant, while also helping clinicians manage volume, electrolytes, and metabolic disturbances. It can therefore serve as either long-term therapy or an interim treatment strategy.