Controlled Release
Controlled Release - Related Videos
11:13
Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
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Cited by 3 •
2015
Scaffolds for tissue engineering need to recapitulate the complex biochemical and biophysical microenvironment of the cellular niche. Here, we show the use of interfacial polyelectrolyte complexation fibers as a platform to create composite, multi-component polymeric scaffolds with sustained biochemical release.
09:11
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Cited by 10 •
2016
We present a facile method to fabricate a biodegradable gelatin-based drug release platform that is magneto-thermally responsive. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and poly(N-isopropylacrylamide-co-acrylamide) within a spherical gelatin micro-network crosslinked by genipin, in conjunction with an alternating magnetic field application system.
11:53
Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
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Cited by 6 •
2017
We present a novel method that uses photo-responsive block copolymers for more efficient spatiotemporal control of gene silencing with no detectable off-target effects. Additionally, changes in gene expression can be predicted using straightforward siRNA release assays and simple kinetic modeling.
08:39
Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
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Cited by 9 •
2017
This manuscript describes the preparation of magnetic and thermal-sensitive microgels via a temperature-induced emulsion without chemical reaction. These sensitive microgels were synthesized by mixing poly(N-isopropylacrylamide) (PNIPAAm), polyethylenimine (PEI) and Fe3O4-NH2 nanoparticles for the potential use in magnetically and thermally triggered drug-release.
07:07
Controlled-release of Chlorine Dioxide in a Perforated Packaging System to Extend the Storage Life and Improve the Safety of Grape Tomatoes
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Cited by 14 •
2017
Here, we describe a protocol for the application of a novel, slow-release ClO2 product that reduces spoilage and extends the shelf life of fresh fruit. The slow-release ClO2 product was added to standard commercial grape tomato packaging and tested against Escherichia coli and Alternaria alternata.
FAQs
These mechanisms regulate how quickly an active substance leaves its carrier or device. Diffusion depends on transport through the material, dissolution depends on the carrier or coating dissolving, and degradation depends on material breakdown. Engineers select or combine these processes to adjust exposure over time, helping match delivery behavior to the performance requirements of a particular application.
Release behavior depends on the carrier or device design and on surrounding conditions. Polymer structure, coating arrangement, capsule configuration, and implantable-device geometry can affect transport. Environmental variables such as pH, temperature, and moisture may also change release when the system is designed to respond to them. Controlling these factors supports more predictable delivery.
A responsive system can alter delivery when conditions such as pH, temperature, or moisture change, whereas a fixed design relies primarily on its built-in transport properties. This distinction matters when the active substance must be released preferentially under selected conditions. In engineering, responsiveness can improve targeting, timing, and material efficiency when the surrounding environment is variable.
Design begins by identifying the required release rate, location, and timing for the active substance. Engineers then select a carrier or device format, such as a polymer matrix, coating, capsule, or implantable device, and choose the transport mechanism. The design is evaluated against the intended exposure, stability, safety, efficiency, and reliability requirements.
The format depends on how the active substance must be delivered and where sustained exposure is needed. Polymer matrices and coatings can regulate transport from a material surface, while capsules and implantable devices provide enclosed delivery configurations. These options support different engineering goals, including precise dosing, improved stability, reduced waste, or longer-lasting performance.
In drug delivery and tissue engineering, the approach can support sustained exposure and controlled dosing. Agricultural systems use it for fertilizers and pesticides, while industrial applications can regulate additives. Across these fields, the engineering value comes from matching delivery to operational needs, which may improve safety, efficiency, stability, reliability, and the use of active materials.