Nonlinear Distortion

Nonlinear distortion is the alteration of a signal caused when a system’s output is not proportional to its input, making it an important concern in engineering design and measurement. As signal amplitude changes, nonlinear components such as amplifiers, sensors, speakers, or circuit elements can generate harmonics and intermodulation products; clipping and saturation are common manifestations when operating limits are exceeded. Engineers analyze nonlinear distortion using spectral measurements and metrics such as total harmonic distortion to evaluate signal fidelity, stability, and performance. Controlling it through linearization, feedback, filtering, or appropriate operating levels improves communication, audio, instrumentation, and power-system applications.

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Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Nonlinear Pharmacokinetics: Causes of Nonlinearity

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2025

Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens. Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...

Research

JoVE Journal - Medicine

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

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Cited by 13 •

2013

We demonstrate methods for the detection of architectural distortion in prior mammograms. Oriented structures are analyzed using Gabor filters and phase portraits to detect sites of radiating tissue patterns. Each site is characterized and classified using measures to represent spiculating patterns. The methods should assist in the detection of breast cancer.

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

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Cited by 2 •

2016

Saturable and reverse saturable scattering were discovered in isolated plasmonic particles and adopted as a novel non-bleaching contrast method in super-resolution microscopy. Here the experimental procedures of detecting and extracting nonlinear scattering are explained in detail, as well as how to enhance resolution with the aid of saturated excitation microscopy.

Research

JoVE Journal - Bioengineering
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Medical-grade Sterilizable Target for Fluid-immersed Fetoscope Optical Distortion Calibration

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Cited by 6 •

2017

This article describes the design and development of a sterilizable custom camera optical distortion calibration target for the peri-operative, fluid-immersed calibration of endoscopes during endoscopic interventions.

Introduction to Nonlinear Inequalities

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2025

Linear and nonlinear inequalities are fundamental for analyzing variable relationships and identifying ranges satisfying specific conditions. A linear inequality involves variables raised only to the first power, resulting in a straight-line graph. This line partitions the coordinate plane into two distinct regions: one that satisfies the inequality and one that does not. Each region represents a set of solutions where the linear relationship holds true under the specified constraint.Nonlinear...

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