Quartz Crystal Microbalance
Quartz Crystal Microbalance - Related Videos
05:13
Quartz-Crystal Microbalance Biosensor-Based Biopanning to Study Protein-Drug Interactions
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2025
This video demonstrates a method to study protein-drug interactions using QCM biosensor-based biopanning of the T7 phage-displayed peptide library. The biopanning of phages displaying a specific peptide on the QCM biosensor allows specific isolation of high-affinity peptides, followed by amino acid sequencing, which helps to identify specific interaction sites on the target protein.
08:21
Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
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Cited by 12 •
2020
The quartz crystal microbalance can provide accurate mass and viscoelastic properties for films in the micron or submicron range, which is relevant for investigations in biomedical and environmental sensing, coatings, and polymer science. The sample thickness influences which information can be obtained from the material in contact with the sensor.
09:46
Adsorption Device Based on a Langatate Crystal Microbalance for High Temperature High Pressure Gas Adsorption in Zeolite H-ZSM-5
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Cited by 1 •
2016
A protocol for high-temperature and high-pressure gas adsorption measurements on zeolite H-ZSM-5 using an adsorption measurement device based on a langatate crystal microbalance is presented. Prior to the adsorption measurements, the synthesis of zeolite H-ZSM-5 on the langatate crystal microbalance sensor by the steam-assisted crystallization (SAC) method is demonstrated.
07:37
Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition
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Cited by 7 •
2015
A protocol is presented for the preparation of piezoelectric macroporous epitaxial films of quartz on silicon by solution chemistry using dip-coating and thermal treatments in air.
07:33
Physical Properties Of Minerals I: Crystals and Cleavage
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2023
Source: Laboratory of Alan Lester - University of Colorado Boulder The physical properties of minerals comprise various measurable and discernible attributes, including color, streak, magnetic properties, hardness, crystal growth form, and crystal cleavage. Each of these properties are mineral-specific, and they are fundamentally related to a particular mineral’s chemical make-up and atomic structure. This experiment examines two properties that stem primarily from symmetric repetition of...
FAQs
For a rigid, uniform film, the Sauerbrey relationship converts the crystal’s resonance-frequency shift into an estimate of areal mass change. The calculation is useful when deposited material remains mechanically coupled to the oscillating surface, because the measured shift then tracks added or removed mass. Engineers can therefore quantify thin-film growth or loss rather than only observe a signal.
Dissipation measurements add mechanical information that frequency alone cannot provide. They indicate how much oscillation energy the surface layer loses, helping characterize viscoelastic films, which combine elastic and fluid-like behavior. This distinction matters when an adsorbed layer is not rigid: a frequency shift may reflect both mass loading and the layer’s mechanical response, so dissipation improves interpretation.
Film rigidity and uniformity determine whether the Sauerbrey relationship can provide a reliable areal-mass estimate. A rigid, evenly distributed layer supports the intended frequency-to-mass interpretation. If the deposited material behaves as a viscoelastic layer, engineers should consider dissipation alongside frequency, because the response can contain information about mechanical behavior as well as interfacial mass change.
A practical Quartz Crystal Microbalance measurement follows the resonance response of an electrode-coated quartz crystal while material accumulates on or leaves its surface. Recording this response in real time links changes in frequency to adsorption or desorption events. The approach lets engineers follow thin-film formation and surface interactions as they occur, rather than relying only on an endpoint measurement.
Engineers apply QCM to thin-film deposition, coating development, biosensor design, corrosion studies, and electrochemical research. These applications share a need to observe small changes at an interface over time. The resulting frequency and dissipation responses can reveal whether material is transferred to the surface and, when appropriate, whether the resulting layer has viscoelastic behavior.
Quartz Crystal Microbalance connects nanoscale mass transfer with measurable changes in a surface-bound system. In coating and deposition work, this supports evaluation of film growth; in corrosion and electrochemical studies, it helps track interfacial processes. Biosensor development likewise benefits from observing surface interactions in real time, providing information about how materials behave at engineered interfaces.