Mouse Oral Surgery
Mouse Oral Surgery - Related Videos
05:34
Oral Delivery of Transformed Yeast Cells into the Mouse Intestinal Immune System
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2025
This video showcases the oral administration of transformed yeast cells into a mouse model. The transformed yeast cells are orally administered using a gavage technique, reaching the mouse's stomach. Later, the cells migrate to the small intestine, where microfold cells engulf them and facilitate their transfer to Peyer's patches and gain access to the intestinal immune system.
07:59
Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
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2026
A unique method to surgically resect oral squamous cell carcinoma tumors established in the oral cavity is shown here.
04:19
Oral Combinational Antiretroviral Therapy to Treat HIV-1 Infection in a Humanized Mouse Model
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2025
This video demonstrates an assay to evaluate the effectiveness of oral combined antiretroviral therapy (oral cART) in a human immunodeficiency virus-1 (HIV-1)-infected humanized mouse model. A combination of drugs targeting HIV-1, including nucleoside reverse transcriptase inhibitors and integrase strand transfer inhibitors, is administered along with a nutritional supplement and antibiotics. Following the consumption of this mixture by the humanized mice infected with HIV-1, the effective...
04:28
Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals
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Cited by 4 •
2016
The following protocol describes a novel method for chronic oral drug administration using an orally dissolving strip (ODS) in lieu of the more commonly used oral gavage method. We demonstrate that preclinical, oral drug delivery using the ODS method represents a safe, convenient, and humane alternative to oral gavage.
12:03
Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
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Cited by 15 •
2011
A comprehensive overview of the techniques involved in generating a mouse model of oral cancer and quantitative monitoring of tumor invasion within the tongue through multi-photon microscopy of labeled cells is presented. This system can serve as a useful platform for the molecular assessment and drug efficacy of anti-invasive compounds.
FAQs
By creating a defined intervention or injury in oral tissues, the model allows researchers to examine immune activity at the site of tissue disruption. Findings can then be related to broader mechanisms of disease, while controlled surgical conditions limit unrelated variables. This approach is especially useful for connecting local inflammatory responses with interactions between oral tissues and the immune system.
Microbial colonization can influence inflammation, tissue repair, and the interpretation of infection-related outcomes. Sterile instruments and careful infection control help limit unintended microbial effects, while standardized procedures make comparisons between experimental groups more reliable. These safeguards allow researchers to better associate observed changes with the intended oral intervention rather than uncontrolled contamination or procedural variation.
A controlled intervention can support analysis of inflammatory responses, microbial colonization, wound healing, and tissue-level interactions with the immune system. Examining these processes together helps researchers assess how oral tissues respond to injury and infection-related conditions. The resulting observations can clarify relationships among local inflammation, repair, and broader disease mechanisms.
Standardization reduces variation in how oral tissues are accessed, manipulated, or injured across experiments. Consistent technique, anesthesia, sterile handling, and postoperative monitoring help limit unrelated differences that could affect inflammation, microbial colonization, or repair. Greater procedural consistency improves reproducibility and strengthens conclusions about the biological effects of the intended intervention.
The procedure requires anesthesia, sterile instruments, controlled access to the relevant oral tissues, and a clearly defined intervention or injury. After surgery, researchers monitor the animals and maintain infection-control practices. These steps help protect experimental consistency while supporting evaluation of tissue responses, microbial changes, and healing after manipulation of the teeth, gums, mucosa, or jaw.
This model is useful when investigators need to study how oral tissue injury or manipulation affects local immunity, infection, and repair. It can provide a controlled setting for examining microbial colonization alongside inflammatory responses and wound healing. Because the intervention is defined and the tissues are anatomically localized, findings can connect oral events with broader immune and disease mechanisms.