Isochronism

Isochronism is the property of a motion or process having a constant duration, often regardless of its starting position or amplitude. In mathematical models, this behavior arises when the governing dynamics produce a fixed period, as in the simple harmonic oscillator described by x'' + ω²x = 0, whose period is 2π/ω and does not depend on amplitude; the cycloid also generates an isochronous descent known as the tautochrone. Isochronism links differential equations, geometry, and dynamical systems, providing idealized principles for analyzing periodic motion and explaining why certain designs, including pendulums and timing mechanisms, can maintain regular intervals.

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Research

JoVE Journal - Biology

Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart

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Cited by 8 •

2015

This article describes the detailed protocol and equipment necessary for dual optical mapping of transmembrane potential (Vm) and free intra-sarcoplasmic reticulum (SR) Ca2+ in the Langendorff-perfused rabbit heart. This method allows for direct observation and quantification of Vm and SR Ca2+ dynamics in the intact heart.

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