Amblyopia Suppression
Amblyopia Suppression - Related Videos
08:34
The Measurement and Treatment of Suppression in Amblyopia
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Cited by 54 •
2012
Amblyopia is a developmental disorder of the visual cortex that is often accompanied by strong suppression of one eye. We present a new technique for measuring and treating interocular suppression in patients with amblyopia that can be deployed using virtual reality goggles or a portable iPod Touch device.
04:29
Visualizing Transcriptional Suppression in Virus-Infected Cells
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2026
Source: Kalveram, B. et al. Using Click Chemistry to Measure the Effect of Viral Infection on Host-Cell RNA Synthesis. J. Vis. Exp. (2013)This video demonstrates the use of click chemistry and fluorescence microscopy to visualize nascent RNA transcription in mammalian cells. It highlights how viral infection suppresses host transcription by comparing fluorescent signals between infected and control cells.
14:01
Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
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2011
Tregs are potent suppressors of the immune system. There is a lack of unique surface markers to define them, hence, definitions of Tregs are primarily functional. Here we describe an optimized in vitro assay capable of identifying immune imbalance in subjects at risk to develop T1D.
03:35
Analysis of Virus-Induced Host Transcriptional Suppression Using Flow Cytometry
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2026
Source: Kalveram, B., et al. Using Click Chemistry to Measure the Effect of Viral Infection on Host-Cell RNA Synthesis. J. Vis. Exp. (2013)This video demonstrates the use of click chemistry and flow cytometry to measure virus-induced suppression of host-cell transcription. Mammalian cells are infected with a virus that expresses a nuclear virulence protein disrupting the host transcription factor complex, while control cells remain transcriptionally active. Incorporation of 5-ethynyl uridine...
02:12
Co-Infiltration Assay for Screening Pathogen Effectors that Suppress Plant RNA Silencing
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2026
Source: Shi, J., et al. Screening and Identification of RNA Silencing Suppressors from Secreted Effectors of Plant Pathogens. J. Vis. Exp. (2020)This video demonstrates a co-infiltration assay for identifying pathogen effector proteins that suppress RNA silencing in Nicotiana benthamiana 16c. A fluorescent reporter and a candidate effector gene are delivered into plant leaves via Agrobacterium. Normally, RNA silencing degrades reporter transcripts, reducing fluorescence. Suppressor effectors...
FAQs
When the eyes send conflicting information during development, neural processing favors the eye supplying the more reliable image and suppresses competing input from the other eye. This unequal treatment of visual signals can produce a persistent difference in acuity between the eyes, making binocular vision assessment important in clinical evaluation.
Strabismus, unequal refractive error, and other disruptions that prevent clear vision can create the mismatched input associated with amblyopia suppression. Although these conditions differ in how they affect the eyes, they can share a developmental consequence: the brain receives signals of unequal quality and increasingly relies on the stronger eye.
Timing matters because visual development is most adaptable during childhood. If suppression persists while these visual pathways are developing, differences in processing and visual acuity may become lasting. Early recognition therefore provides an opportunity to identify the imbalance and consider corrective or therapeutic measures while the developing system remains more responsive.
Clinical assessment examines binocular vision alongside differences in visual acuity between the eyes. This approach considers whether the eyes are providing coordinated, usable information rather than evaluating each eye in isolation. The findings help clinicians understand the visual imbalance and select an appropriate strategy for correcting the underlying problem or encouraging use of the affected eye.
Correcting refractive errors addresses one source of unequal or unclear visual input. By improving the optical quality of the affected eye’s image, clinicians can reduce a mismatch that may encourage the brain to favor the other eye. This correction forms part of treatment planning and may be combined with therapies designed to increase use of the affected eye.
Such therapies may be considered when suppression has produced reduced processing or acuity in one eye and the visual imbalance needs active treatment. They are intended to encourage the affected eye to contribute more consistently, alongside correction of relevant refractive errors. Early recognition is especially relevant because childhood visual development offers the greatest adaptability.