L-shaped Excision
L-shaped Excision - Related Videos
01:54
Base Excision Repair
0 Views •
2020
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template. The first step of...
03:37
Molecular Shape and Polarity
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2020
Dipole Moment of a Molecule Polar covalent bonds connect two atoms with differing electronegativities, leaving one atom with a partial positive charge (δ+) and the other atom with a partial negative charge (δ–), as the electrons are pulled toward the more electronegative atom. This separation of charge gives rise to a bond dipole moment. The magnitude of a bond dipole moment is represented by the Greek letter mu (µ) and is given by the formula shown here, where Q is the magnitude of the...
09:03
Morphometric Analyses of Shape: The Analysis Software Toolbox for Craniofacial Shape Quantification in Zebrafish
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2026
This work describes a protocol for quantifying craniofacial cartilage shape using free software (tpsDigs2, MorphoJ, and PAST) to measure changes in facial structure in zebrafish larvae.
02:52
VSEPR Theory and the Basic Shapes
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2020
Overview of VSEPR Theory Valence shell electron-pair repulsion theory (VSEPR theory) enables us to predict the molecular structure, including approximate bond angles around a central atom, of a molecule from an examination of the number of bonds and lone electron pairs in its Lewis structure. The VSEPR model assumes that electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between these electron pairs by maximizing the distance between them.
01:46
Nucleotide Excision Repair
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2020
Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged DNA can be detected and repaired in a process called nucleotide excision repair (NER). NER employs a set of specialized proteins that first scan DNA to detect a damaged region. Next, NER proteins separate the strands and excise the damaged area. Finally, they coordinate the replacement with new, matching nucleotides.DNA distortion and damageCells are...
FAQs
The two intersecting limbs can orient the resulting wound along relevant anatomical boundaries or skin-tension lines. This planning may help the surgeon approach the target while limiting unfavorable tension during closure. The benefit depends on local tissue flexibility and the anatomical site, so the same design may perform differently in different regions.
Suitability depends on the lesion’s extent, the amount and flexibility of surrounding tissue, and the location of the abnormality. Surgeons also consider nearby structures and the intended repair. These factors influence whether the planned defect can be closed directly or will require a reconstructive method after tissue removal.
Careful margin planning determines how much tissue is removed around the target while helping the surgeon account for adjacent structures. Because the incision creates a directional defect, its placement also affects access and later repair. Balancing removal with preservation supports effective treatment while reducing avoidable difficulty during wound closure.
A linear excision creates a single directional wound, whereas this approach uses two intersecting limbs to improve access or align the defect with anatomical boundaries and skin-tension lines. That geometry can offer different options for managing wound tension, but its usefulness still depends on tissue flexibility, lesion extent, location, and the planned closure.
Planning begins with assessing the localized abnormality, its extent, the anatomical site, surrounding tissue flexibility, and nearby structures. The surgeon then selects the incision orientation and considers appropriate margins. After removal, the defect is evaluated for direct suturing or reconstruction, with closure chosen to address the resulting wound and its tension.
In medicine, L-shaped excision can support removal of selected cutaneous lesions and other localized abnormalities when access, tissue preservation, and wound management must be considered together. The intended outcome is removal of the target with a repair suited to the defect. Results depend on lesion extent, location, tissue flexibility, margins, and closure planning.