Programmed Ventricular Stimulation
Programmed Ventricular Stimulation - Related Videos
07:29
Programmed Electrical Stimulation in Mice
0 Views •
Cited by 48 •
2010
Programmed electrical stimulation provides the ability to determine conduction properties of the heart, and the possibility to induce and terminate cardiac arrhythmias using various pacing protocols. Using a transvenous catheter, intracardiac electrogram recordings can be obtained in mice following programmed electrical stimulation protocols to identify arrhythmogenic substrates.
03:18
Stimulation of the Intracardiac Nervous System to Assess Susceptibility to Arrhythmia
0 Views •
2025
Source: Jungen, C., et al. Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System. J. Vis. Exp. (2018).The video demonstrates an ex vivo technique for stimulating the intracardiac nervous system to assess the heart’s susceptibility to arrhythmia. Using a perfusion apparatus, an isolated mouse heart is perfused with an oxygenated buffer. The intracardiac nervous system is then stimulated at a high frequency to induce arrhythmias.
07:51
Murine Short Axis Ventricular Heart Slices for Electrophysiological Studies
0 Views •
Cited by 3 •
2017
Here, we describe the preparation of viable ventricular slices from adult mice and their use for sharp electrode action potential recordings. These multicellular preparations provide a preserved in vivo like tissue structure, which makes them a valuable model for electrophysiological and pharmacological studies in vitro.
14:39
Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
0 Views •
Cited by 44 •
2014
Current knowledge on the cellular basis of cardiac diseases mostly relies on studies on animal models. Here we describe and validate a novel method to obtain single viable cardiomyocytes from small surgical samples of human ventricular myocardium. Human ventricular myocytes can be used for electrophysiological studies and drug testing.
11:02
Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
0 Views •
Cited by 17 •
2010
In this article, we examine the methodology and considerations relevant to the combination of TMS and fMRI to examine the effects of brain stimulation on the default network.
FAQs
The test varies the timing of ventricular electrical impulses, including precisely timed premature stimuli, and records how the ventricles respond. Differences in the resulting response can expose abnormalities in conduction pathways or suggest the presence of reentry circuits, in which electrical activity repeatedly circulates through cardiac tissue. This makes timing patterns central to interpreting ventricular electrical behavior.
Whether controlled stimulation induces sustained tachycardia or fibrillation provides information about ventricular electrical stability and arrhythmia risk. An inducible rhythm demonstrates that the ventricles can support a serious abnormal rhythm under the tested conditions, while the absence of induction supplies different information about the response. These findings contribute to clinical risk assessment in selected patients.
Conduction pathways determine how electrical impulses travel through the ventricles, whereas reentry circuits can allow activity to continue in a repeating loop. Programmed Ventricular Stimulation examines ventricular responses after carefully timed impulses, so the observed behavior can provide evidence about these mechanisms. Interpreting both helps connect an induced rhythm with the underlying electrical organization of the heart.
During the procedure, intracardiac electrodes deliver the pacing sequence and premature stimuli while cardiac electrical signals and blood pressure are monitored. Recording these measurements together allows clinicians to relate the ventricular electrical response to hemodynamic changes. The combined information supports assessment of the induced response rather than relying only on whether an abnormal rhythm appears.
The assessment uses intracardiac electrodes to provide a sequence of paced impulses followed by precisely timed premature stimuli. Clinicians observe the resulting ventricular response while recording cardiac signals and blood pressure. This controlled sequence is adjusted through the timing of delivered stimuli, allowing the evaluation to focus on conduction behavior, inducibility of abnormal rhythms, and electrical stability.
Clinicians use Programmed Ventricular Stimulation in selected patients when information about abnormal rhythms or arrhythmia risk is needed. Findings may help guide decisions about catheter ablation, antiarrhythmic therapy, or implantable cardioverter-defibrillator treatment. Its value is therefore not limited to diagnosis: the induced response can contribute to choosing among different management strategies.