Receptor-mediated Transcytosis
Receptor-mediated Transcytosis - Related Videos
02:28
Assessing Transcytosis of E. coli Across Intestinal Epithelial Monolayers
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2025
Source: Islam, A., et al., Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates. J. Vis. Exp. (2023)This video demonstrates the procedure for assessing transcytosis of neonatal Escherichia coli across intestinal epithelial monolayers using transwell inserts, electrical resistance measurement, and bacterial quantification.
01:20
Receptor-Mediated Endocytosis
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2023
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle. Clathrin-Mediated Endocytosis of LDL One well-characterized example of receptor-mediated endocytosis is the...
01:20
Receptor-mediated Endocytosis
0 Views •
2023
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle. Clathrin-Mediated Endocytosis of LDL One well-characterized example of receptor-mediated endocytosis is the...
01:48
Receptor-mediated Endocytosis
0 Views •
2026
Receptor-mediated endocytosis is a process through which bulk amounts of specific molecules can be imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle and give it its round form.Clathrin-Mediated Endocytosis of LDLOne well-characterized example...
01:15
Transcytosis of IgG
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2023
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis. IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
FAQs
Cargo selectivity begins at the cell surface: a molecule must bind a compatible receptor to enter this transport pathway. That recognition connects the intended ligand with vesicle formation and movement through the cell. In medical applications, this selectivity provides a basis for directing therapeutic agents toward endothelial transport routes and protected tissues.
Release at the opposite membrane makes the process directional rather than merely internal. After endocytosis, the ligand-containing vesicle crosses the polarized cell and undergoes exocytosis on the far side, placing its cargo beyond the cellular barrier. This final step is essential for achieving transport across endothelial cells and improving access to protected tissues.
Receptor choice matters because only receptors that undergo transcytosis can provide a route through the endothelial cells forming this barrier. Selecting such a receptor connects ligand recognition with vesicle trafficking and release on the opposite side. In medicine, that relationship may increase delivery of therapeutic agents to neural tissue that is otherwise protected.
Therapeutic development can harness receptors that transport bound cargo across endothelial cells. The goal is not simply to achieve receptor binding, but to support the full sequence of internalization, intracellular trafficking, and release on the tissue-facing membrane. This approach may improve targeted delivery and help treatments reach protected tissues involved in neurological or systemic disease.
Endothelial cells are important because they can form polarized barriers with distinct surfaces facing different compartments. That organization gives vesicles a defined route from one membrane to the other, allowing cargo to cross the cell rather than remain on its entry side. This feature explains the medical interest in endothelial transport at the blood-brain barrier.
The pathway supports targeted drug delivery by linking therapeutic cargo to receptor recognition and cellular transport. Its potential benefit is improved access to protected tissues, including neural tissue behind the blood-brain barrier. These principles connect cellular transport research with treatment development for neurological and systemic diseases where delivery to the relevant tissue is a central objective.