Splenic Vessel Preservation
Splenic Vessel Preservation - Related Videos
08:54
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Cited by 29 •
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We describe a method of ex vivo machine perfusion of human liver grafts at subnormothermic temperature (21 °C).
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Stability of Floating Vessels
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2023
Source: Alexander S Rattner and Kevin Rao Li Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA The objective of this experiment is to demonstrate the phenomenon of stability of floating vessels - the ability to self-right when rolled over to the side by some external force. Careful design of hull shapes and internal mass distribution enables seagoing vessels to be stable with low drafts (submerged depth of hull), improving vessel...
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Induction of Graft Versus Host Disease in Mouse Models via Allogeneic Bone Marrow and Splenic Cell Transplantation
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This video demonstrates the induction of intestinal graft-versus-host disease, GvHD, in a lethally-irradiated recipient mouse using allogeneic hematopoietic stem cells and GvHD-inducing splenic alloreactive T lymphocytes. This protocol helps establish a severe acute intestinal GvHD model to understand the mechanism of the disease and develop innovative therapeutic options.
05:56
Operation of High-pressure Reactor Vessels
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2023
Robert M Rioux, Pennsylvania State University, University Park, PA The use of gases in a synthetic chemistry laboratory is essential for carrying out a variety of highly facile and atom economical transformations. Reactions such as hydrogenation, oxidation, and amination require the use of gases like hydrogen, oxygen, and ammonia. Due to the poor solubility of these gases in typical reactant solutions, high pressures are necessary to achieve a meaningful reaction rate. Not only are these gases...
07:32
Purification of Mouse Brain Vessels
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Cited by 90 •
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We describe a protocol allowing the purification of the mouse brain's vascular compartment. Isolated brain vessels include endothelial cells linked by tight junctions and surrounded by a continuous basal lamina, pericytes, vascular smooth muscle cells, as well as perivascular astroglial membranes.
FAQs
The central technical challenge is separating pancreatic tissue from the splenic artery and vein without compromising either vessel. Small arterial and venous branches encountered during dissection must be controlled individually, while the main artery continues to deliver blood and the main vein remains available for drainage. This balance supports viable splenic tissue after resection.
Preserving both inflow and outflow matters because the spleen’s continued presence is linked to retained immune function. The strategy also avoids additional risks associated with removing the spleen, particularly susceptibility to severe infections and vascular complications. Vessel preservation is therefore not merely an anatomic goal; it can influence postoperative organ function and risk.
The approach is suitable only when the relevant anatomy and the extent of disease allow the pancreatic tissue to be separated from the splenic vessels. If that relationship cannot be maintained safely, organ preservation may not be possible. Careful assessment therefore guides whether spleen-preserving distal pancreatectomy can be considered.
The procedure centers on careful dissection of pancreatic tissue away from the splenic artery and vein. As separation proceeds, small arterial and venous branches are controlled, while the main vessels are protected from injury. Maintaining this sequence allows treatment of the distal pancreas or adjacent tissues while retaining the spleen when the anatomy permits.
The intended result is treatment of the affected distal pancreatic or adjacent tissue without sacrificing the spleen or disrupting its principal blood supply and venous drainage. Successful preservation retains the organ’s potential immune function and avoids risks associated with splenectomy. The result depends on maintaining the main splenic vessels throughout the dissection.
Clinicians may consider spleen-preserving distal pancreatectomy when disease involves the distal pancreas or nearby tissues, but the anatomy and disease extent still permit safe separation from the splenic vessels. Its medical relevance lies in combining treatment of the affected region with organ preservation, thereby retaining splenic function and avoiding selected consequences of splenectomy.