Tumor Identification
Tumor Identification - Related Videos
10:34
Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR
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Cited by 3 •
2013
A method of identifying unknown drivers of carcinogenesis using an unbiased approach is described. The method uses the Sleeping Beauty transposon as a random mutagen directed to specific tissues. Genomic mapping of transposon insertions that drive tumor formation identifies novel oncogenes and tumor suppressor...
11:09
Rodent Identification I
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2015
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN A fundamental requirement of biomedical research is the proper identification of research animals. It is essential that the right animal is utilized for procedures and data collection. Laboratory mice and rats can be identified with the following permanent methods: ear tags, ear punch codes, microchip implantation, tail tattoos for adult mice, and toe tattoos for neonates. Temporary methods of...
14:12
Rodent Identification II
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2015
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN Animal records must be accurately maintained to ensure that data collection is correct. Records range from maintaining information on cage cards to having a detailed database with all of the relevant information on each animal. The primary component of recordkeeping is the individual identification of research animals. There are a variety of methods suitable for identifying mice and rats. This...
02:43
Tumor Implantation and Injection of a Tumor Vaccine in a Mouse Model
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2025
This video demonstrates a cell-based tumor vaccination assay. A mouse, intradermally injected with B16-F10 melanoma cells for tumor formation, is vaccinated with B16-F10 cells secreting Flt3L cytokine near the developed tumor. The secreted Flt3L from the vaccine promotes the maturation and proliferation of dendritic cells that then present tumor antigens to T cells in lymph nodes, triggering a targeted anti-tumor immune response.
06:23
A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
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Cited by 8 •
2017
This protocol describes the generation of murine orthotopic bladder tumors in female C57BL/6J mice and the monitoring of tumor growth.
FAQs
These imaging methods provide the initial view of an abnormal mass and help clinicians characterize its location and features before tissue examination. Ultrasound, CT, and MRI offer complementary information, so findings from one study may be evaluated alongside other imaging or examination results. Imaging therefore supports decisions about whether further assessment, including biopsy, is appropriate.
Histopathology examines tissue architecture and cellular features directly, providing evidence that imaging alone cannot establish. This examination helps classify the tumor and can contribute to grading, which describes important characteristics of its abnormal tissue. The resulting microscopic assessment gives clinicians a stronger basis for diagnosis and treatment planning than appearance on imaging alone.
Immunohistochemistry examines tumor-associated proteins within tissue and adds information beyond architecture and cell appearance. These protein patterns can help refine tumor classification when microscopic findings require further characterization. By integrating this evidence with histopathology, clinicians can improve the specificity of the assessment and support decisions about prognosis or subsequent testing.
Molecular testing can reveal alterations associated with a tumor, adding a genetic layer to findings from imaging and tissue analysis. The identified alterations may provide information about prognosis or indicate relevance to targeted therapy. This makes molecular results useful not only for refining tumor characterization but also for connecting diagnostic findings with potential treatment selection.
Evaluation commonly begins with a physical examination and imaging to locate and characterize the mass. When tissue is needed, clinicians use biopsy followed by histopathology, with immunohistochemistry or molecular testing added when supported by the clinical question. The combined results guide classification, grading, staging, and decisions about patient care rather than relying on one finding alone.
Tumor identification provides reference information that clinicians can use to monitor disease progression and response to treatment. Follow-up may compare later clinical or imaging findings with the original characterization, while tissue or molecular information can remain relevant to classification and prognosis. This ongoing assessment helps inform care as the patient's disease status changes.