Axonal Loss
Axonal Loss - Related Videos
01:10
Line Loss
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2024
The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss. Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
12:27
Piping Networks and Pressure Losses
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2023
Source: Alexander S Rattner, Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA This experiment introduces the measurement and modeling of pressure losses in piping networks and internal flow systems. In such systems, frictional flow resistance from channel walls, fittings, and obstructions causes mechanical energy in the form of fluid pressure to be converted to heat. Engineering analyses are needed to size flow hardware to ensure...
03:24
Two-Photon Laser Axotomy: A Method to Injure Axons in Zebrafish Embryos and Observe Axonal Recovery
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2023
This video describes the method to injure axons in zebrafish embryos using two photon laser axotomy and observing axonal recovery from injury.
01:18
Reducing Line Loss
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2024
In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this. With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
09:25
Laser Nanosurgery of Cerebellar Axons In Vivo
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Cited by 7 •
2014
Two-photon imaging, coupled to laser nanodissection, are useful tools to study degenerative and regenerative processes in the central nervous system with subcellular resolution. This protocol shows how to label, image, and dissect single climbing fibers in the cerebellar cortex in vivo.
FAQs
After an axon is severed, the disconnected distal segment can degenerate because axonal transport is disrupted and the axon’s cytoskeleton breaks down. This sequence separates the damaged segment from the neuronal cell body and can be accompanied by myelin loss. The resulting structural deterioration helps explain why signal transmission and neural connectivity may decline after injury.
Axonal loss can arise through several initiating conditions, including physical injury, metabolic stress, toxic stress, and neurodegenerative disease. These triggers are different, but they can converge on impaired axonal integrity and connectivity. Distinguishing the initiating context matters because the same measurable loss may reflect injury-related disruption, cellular stress, or disease-associated degeneration.
Limited regeneration means that damage may not be fully compensated for by restoring the original pathway. When axonal connections remain reduced, communication between nerve cells and their targets can stay impaired. This makes axon regeneration and repair important research goals, particularly for understanding whether lost connectivity can be prevented or recovered.
Measurements of axonal loss provide a way to characterize disease progression rather than relying only on symptoms. In neuroscience studies, these measurements can be related to sensory and motor deficits, helping investigators connect structural damage with functional impairment. They also provide an outcome for comparing disease states or evaluating whether a neuroprotective treatment changes the course of degeneration.
A reduction in axonal connections can disrupt communication between nerve cells and their targets, producing sensory or motor deficits. This network-level consequence is why axonal loss is studied as a marker of neurological dysfunction, not merely as an isolated cellular change. Linking structural loss with these functional effects helps clarify how neural damage appears in behavior or clinical function.
In treatment studies, axonal loss can serve as an outcome for testing neuroprotective strategies. A treatment that reduces measured loss could indicate preservation of neural connectivity, whereas continued degeneration may signal limited protection. The same assessment framework supports research on disease progression and helps compare preservation-focused approaches with efforts aimed at axon regeneration or repair.