Repetitive Concussive Head Injury
Repetitive Concussive Head Injury - Related Videos
05:42
A Repetitive Concussive Head Injury Model in Mice
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Cited by 5 •
2016
Concussion presents the most common type of traumatic brain injury. Therefore, a repetitive concussive animal model, which replicates the important features of an injury in patients, may provide a means to study concussion in a rigorous, controlled, and efficient manner.
04:13
Modeling Repetitive Concussive Head Injuries in a Mouse Model
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2025
Source: Yang, Z., et.al. A Repetitive Concussive Head Injury Model in Mice. J. Vis. Exp. (2016).This video demonstrates the induction of repetitive concussive head injuries in a mouse using an electromagnetic impact device. The procedure involves positioning the impact tip between the interfrontal and lambdoid sutures on the skull of an anesthetized mouse and using a probe tip to precisely set the impact depth. The impact is delivered at a controlled velocity and depth to simulate mild...
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
07:02
An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
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Cited by 5 •
2011
This article provides an overview of a multi-modal approach to mild traumatic brain injury diagnosis and recovery in youth. This approach combines neuropsychological testing with functional magnetic resonance imaging and the Head Impact Telemetry System to monitor the relationship between head impacts and brain activity during cognitive testing.
07:01
A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
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Cited by 2 •
2025
Pediatric concussions can result in long-term sequelae with physiological and psychological perturbations. This pediatric concussion mouse model results in long-term neuroinflammation, white matter alterations, and neuronal modifications with behavioral dysfunction. The model can be adapted to differential impact locations or repeated concussions to assess lifetime changes.
FAQs
Repetitive impacts can affect brain function through more than one physical pathway. Rapid acceleration-deceleration and rotational forces create biomechanical stress, which is associated with altered neuronal signaling, metabolism, and network function. These changes help explain why neurological effects may occur even when evaluation does not show visible structural damage.
Concussion-related dysfunction may arise from temporary changes in how neurons signal, use energy, and communicate across networks rather than from an obvious structural lesion. In neuroscience, this distinction is important because headache, dizziness, impaired concentration, and altered balance can reflect disrupted brain function even when conventional observation does not reveal visible damage.
A subsequent impact before recovery may increase the likelihood that symptoms persist or worsen. The concern centers on the brain’s ongoing functional disruption, including changes in neuronal signaling, metabolism, and network activity. Consequently, recovery status becomes relevant when clinicians and researchers consider whether a person should return to activity.
Outcomes are not uniform, even when people experience repeated head impacts. The overview identifies variation in symptoms and recovery, while noting that effects may include headache, dizziness, concentration problems, and altered balance. This variability makes individualized assessment important and limits conclusions based solely on the number of impacts.
Clinical assessment helps identify ongoing effects and informs decisions about returning to activity. Relevant concerns include persistent or worsening headache, dizziness, impaired concentration, and altered balance, along with the person’s recovery status. This approach supports safer decision-making by recognizing that another impact before recovery may have more serious functional consequences.
Research extends across sports, military, and occupational settings where repeated impacts may occur. It supports improved assessment, injury-prevention strategies, and return-to-activity decisions, while also examining possible long-term neurological effects. These applications connect neuroscience findings about signaling, metabolism, and network function with clinical care and practical safety decisions.