Herbal Extracts
Herbal Extracts - Related Videos
07:34
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
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Cited by 13 •
2012
Sepsis refers to a systemic inflammatory response syndrome resulting from a microbial infection, and can be simulated by a surgical technique termed cecal ligation and puncture (CLP). Here we describe a method to use CLP-induced animal model to screen medicinal herbs for therapeutic agents.
08:07
Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
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Cited by 6 •
2017
Here, we present the preparation of an er-xian decoction (EXD) in four steps—soaking, decoction, filtration, and concentration—and demonstrate the administration of a prepared EXD-containing serum to rats. These methods are applicable to the in vivo and in vitro study of herbal decoctions such as traditional Chinese medicines.
02:55
Extraction - Concepts
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2020
Extraction Extraction is a common technique used in organic chemistry to isolate a target compound. In the extraction process, a solute is transferred from one phase to another to separate it from unreacted starting materials or impurities. Extraction is also used to facilitate the isolation of a solute from a reaction solvent that is difficult to remove by evaporation, such as a solvent with a high boiling point. Generally, there are three types of extractions. First, in solid-liquid...
19:00
Extraction - Student Protocol
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2020
Source: Lara Al Hariri and Ahmed Basabrain at the University of Massachusetts Amherst, MA, USA Cellulose RecoveryExpand Extraction and filtration can separate compounds based on their solubility properties. In this lab, you'll separate a mixture of cellulose, caffeine, and benzoic acid based on their solubilities in dichloromethane, or DCM, and water. Caffeine and benzoic acid are both soluble in DCM, but cellulose is not. Thus, in this part, you'll first dissolve as much of the mixture as...
06:42
Extraction of Biomarkers from Sediments - Accelerated Solvent Extraction
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2023
Source: Laboratory of Jeff Salacup - University of Massachusetts Amherst The distribution of a group of organic biomarkers called glycerol-dialkyl glycerol-tetraethers (GDGTs), produced by a suite of archaea and bacteria, were found in modern sediments to change in a predictable manner in response to air or water temperature1,2. Therefore, the distribution of these biomarkers in a sequence of sediments of known age can be used to reconstruct the evolution of air and/or water temperature on...
FAQs
Solvent choice can determine which constituents enter an herbal extract and therefore shape its chemical profile. Pharmacological interpretation depends on recognizing that different solvents may produce preparations with different compositions and potentially different biological effects. Comparing extracts made under defined solvent conditions helps investigators relate observed activity to specific chemical mixtures.
The selected plant part and processing conditions can alter the constituents recovered from the source material. This matters because extract composition affects chemical characterization and the interpretation of pharmacological findings. Recording these variables allows researchers to compare preparations more meaningfully, assess consistency, and determine whether differences in activity may reflect processing rather than a different biological mechanism.
Chemical characterization identifies constituents present in a preparation and helps connect its composition with observed pharmacological effects. Because the material may contain multiple biologically active compounds, researchers can examine therapeutic activity and potential toxicity without treating an observed effect as evidence for one compound alone. This supports more precise mechanism studies and interpretation.
A typical workflow begins by selecting extraction conditions and producing the preparation through a suitable process, such as maceration, infusion, or solvent-based separation. Researchers then characterize its chemical profile and investigate potential mechanisms of action, therapeutic effects, and toxicity. This sequence connects how an extract was prepared with the biological outcomes observed in testing.
Standardization supports more consistent herbal extract preparations and strengthens comparisons among research results. Used alongside chemical characterization, it helps investigators relate a preparation’s composition to studies of efficacy, safety, and biological activity. These controls are particularly valuable when extracts are considered for formulation development or drug discovery, where reliable material quality is important.
Researchers may study herbal extracts during drug discovery, formulation development, and evaluations of efficacy or safety. Pharmacology also examines their potential toxicity and interactions, while quality assessment addresses differences in chemical composition among preparations. Together, these investigations help determine whether an extract has a useful therapeutic profile and what evidence is needed before broader development.