Septic Shock Risk
Septic Shock Risk - Related Videos
09:48
Drosophila Adult Olfactory Shock Learning
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Cited by 36 •
2014
The method to measure adult Drosophila associative memory is described. The assay is based on the ability of the fly to associate an odor presented with a negative reinforcer (electric shock) and then recall this information at a later time, allowing memory to be measured.
11:01
Bacterial Transformation: The Heat Shock Method
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2023
Transformation is the process that occurs when a cell ingests foreign DNA from its surroundings. Transformation can occur in nature in certain types of bacteria. In molecular biology, transformation is artificially reproduced in the lab via the creation of pores in bacterial cell membranes. Bacterial cells that are able to take up DNA from the environment are called competent cells. In the laboratory, bacterial cells can be made competent and DNA subsequently introduced by a procedure called...
07:15
In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
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Cited by 2 •
2013
We demonstrate how to perform macrophage MR imaging using ultrasmall superparamagnetic contrast agent (USPIO) in septic arthritis, allowing an initial and longitudinal in vivo non-invasive evaluation of macrophages infiltration and an assessment of therapy efficacy.
01:16
Shock Waves
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2023
While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs. When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high pressures...
19:15
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Cited by 40 •
2014
The NICU Network Neurobehavioral Scale (NNNS) was developed as an assessment for the at-risk infant. The purpose of this article is to describe the NNNS, provide video examples of the NNNS procedures and discuss the ways in which the exam has been used.
FAQs
Inflammatory mediators can drive widespread vasodilation, which lowers vascular tone, while increased vascular permeability allows fluid movement out of the circulation. Impaired blood flow further limits tissue perfusion. Together, these changes can create a cycle in which reduced effective circulation contributes to hypotension and organ dysfunction.
Persistent hypotension may reflect more than a simple lack of circulating fluid. Widespread vasodilation can continue to reduce vascular tone, increased permeability can promote fluid loss from the circulation, and impaired blood flow can limit effective tissue delivery. These mechanisms help explain why clinicians must assess both blood pressure and signs of tissue hypoperfusion.
Risk assessment draws on several categories of evidence rather than one isolated measurement. Clinicians consider the severity of infection, vital signs, laboratory findings, existing comorbidities, and signs of organ injury. Reviewing these factors together helps identify patients whose infection and host response may be progressing toward circulatory failure and complications.
Assessment begins with evaluating the infection and then examining vital signs, laboratory findings, comorbidities, and evidence of organ injury. The clinical team uses this combined picture to judge severity and monitor for deterioration. Repeated evaluation is important because changing circulation, perfusion, or organ function can alter the level of concern.
Early recognition supports prompt antimicrobial treatment, fluid resuscitation, and hemodynamic monitoring. These measures address the infection while supporting circulation and tracking the patient’s response. When findings suggest worsening instability or organ injury, escalation of care becomes important so that treatment intensity and monitoring can match the developing risk.
Escalation is particularly relevant when hypotension, tissue hypoperfusion, or organ dysfunction persists or worsens despite initial fluid replacement. Hemodynamic monitoring provides information about circulatory status, while ongoing review of vital signs, laboratory findings, and organ injury helps identify deterioration. This approach supports timely adjustment of treatment and may limit shock-related complications.