4.12
Biological functions such as metabolic pathways or cell signaling pathways are regulated by feedback mechanisms, which comprise negative and positive feedback loops.
Positive feedback occurs when the product of a process stimulates further increase in its production, leading to an increased response.
The process of blood clotting is one of the common examples of a positive feedback loop.
A cut in the blood vessel wall acts as a stimulus that triggers the vessels and nearby platelets to release chemical signals, activating several clotting factors and attracting platelets to the site of injury, initiating a blood clot. The platelets secrete chemical signals to attract more platelets to the site until the developing clot completely seals off the wound.
A negative feedback loop occurs when the product of a reaction reduces the initial stimulus.
For example, when the blood glucose levels increase, the pancreas releases insulin, which triggers glucose uptake by liver cells, reducing the blood glucose levels.
Once the blood glucose levels are restored, the pancreas stops the production of insulin.
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of…
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