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The 2009 Lindau Nobel Laureate Meeting

The 2009 Lindau Nobel Laureate Meeting: Werner Arber, Physiology or Medicine 1978

Article doi: 10.3791/1571
March 10th, 2010 Usage Statistics

Summary March 10th, 2010

Swiss microbial geneticist, Werner Arber shared the 1978 Nobel Prize in Physiology or Medicine with Hamilton Smith and Daniel Nathans for their discovery of restriction endonucleases. Arber found that viral DNA introduced into a non-specific bacterial host was changed, while host DNA was protected by methylation. He theorized that a microbial enzyme cut the DNA into smaller pieces, while at the same time, the methylated host DNA was protected from its own enzymes. Later work done by Nathans and Smith validated his theory, which laid the foundation for recombinant DNA technology.

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