Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated administration.

Advantages of intermittent infusion: This method is particularly beneficial for drugs that are poorly tolerated when given as a rapid IV bolus. By delivering the drug more gradually, intermittent infusion minimizes the likelihood of toxicity or side effects. For example, aminoglycosides such as gentamicin require high peak plasma concentrations to achieve antimicrobial efficacy while maintaining low trough levels to prevent nephrotoxicity and ototoxicity. Intermittent IV infusion achieves this balance more effectively than a single bolus or continuous infusion.

Intermittent IV infusion provides a flexible and effective strategy for delivering medications that require specific pharmacokinetic and pharmacodynamic considerations. It optimizes therapeutic outcomes while reducing the risks of toxicity and side effects.