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04:39 min
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April 05, 2010
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Goal of the presentation is to demonstrate a highly reproducible method to generate matrix associated stem cell implants in cartilage defects, which can be visualized with MR imaging. Stem cells are labeled with FDA-approved Ferumoxides, mixed with agarose, implanted into cartilage defects and imaged with a 7T MR scanner.
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ImplantationFerumoxides Labeled Human Mesenchymal Stem CellsCartilage DefectsMatrix Associated Stem Cell ImplantsCartilage RegenerationArthritic Joint InjuriesTraumatic Joint InjuriesAdult Mesenchymal Stem CellsChondrogenic LineageCell-based Articular Cartilage Repair TechnologiesAutologous MSCsCell CulturesDifferentiation PotentialChondrogenic DifferentiationScaffoldExtracellular Matrix ExpansionAgarose ScaffoldHyaline CartilageImmune ResponsesLong-term RetentionIron Oxide NanoparticlesMR Imaging Techniques
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Nedopil, A. J., Mandrussow, L. G., Daldrup-Link, H. E. Implantation of Ferumoxides Labeled Human Mesenchymal Stem Cells in Cartilage Defects. J. Vis. Exp. (38), e1793, doi:10.3791/1793 (2010).
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