Name: Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive (Video) | JoVE Journal
Uploaded: 2007-07-04T00:00:00.000+00:00
Duration: 10 min 21 s
Description: Learn about genetic drive strategies for controlling mosquito populations using Wolbachia pipientis. Dr. Jason Rasgon discusses how this endosymbiotic bacterium can spread beneficial genes through vector populations to combat malaria.

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population replacement strategies for controlling vector populations and the use of wolbachia pipientis for genetic drive

Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive

In this video, Jason Rasgon discusses population replacement strategies to control vector-borne diseases such as malaria and dengue. "Population replacement" is the replacement of wild vector populations (that are competent to transmit pathogens) with those that are not competent to transmit pathogens. There are several theoretical strategies to accomplish this. One is to exploit the maternally-inherited symbiotic bacteria Wolbachia pipientis. Wolbachia is a widespread reproductive parasite that spreads in a selfish manner at the extent of its host's fitness. Jason Rasgon discusses, in detail, the basic biology of this bacterial symbiont and various ways to use it for control of vector-borne diseases.

In this interview, Jason Rasgon explains the concept of genetic drive and the characteristics of an effective gene drive system. The use of the endosymbiotic bacterium, Wolbachia pipientis, as a means to spread genes through mosquito populations, is hypothesized.

In this video, Jason Rasgon discusses population replacement strategies to control vector-borne diseases such as malaria and dengue. "Population ...

So my name's Dr.Jason Rascon. I'm an assistant professor in the Johns Hopkins Bloomberg School of Public Health in the Department of Molecular Microbiology and Immunology, and also in the Johns Hopkins Malaria Research Institute. And I'm broadly interested in the relationship between the genetics of vector populations and the epidemiology of vector-borne Pathogens.So malaria Is the most important vector-borne disease in the world today. It's a huge killer. It kills, the stats vary somewhere between one and 3 million people per year.Most of them are children under five in Africa. So it's an enormous problem. And just in, that's just in terms of the mortality, but it also is a huge burden in terms of morbidity and public health and burdens on the economy of these, these areas where, where it's afflicted, it really is a problem.You know, in South America and Africa and Asia, it's, it's, it's, it's a sort of a worldwide problem and it is Reemerging. So Gene drive system is what makes these strategies in theory, economically possible. So the idea is that you can essentially see the population with a very small number of modified insects.And the mechanism, the gene drive mechanism will s

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Research

JoVE Journal

Biology

Charles Taylor and John Marshall explain the utility of mathematical modeling for evaluating the effectiveness of population replacement strategy.  Insight is given into how computational models can provide information on the population dynamics of mosquitoes and the spread of transposable elements through A. gambiae subspecies.  The ethical considerations of releasing genetically modified mosquitoes into the wild are discussed.

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

In this candid interview, Anthony A. James explains how mosquito genetics can be exploited to control malaria and dengue transmission.   Population replacement strategy, the idea that transgenic mosquitoes can be released into the wild to control disease transmission, is introduced as well as the concept of genetic drive and the design criterion for an effective genetic drive system.  The ethical considerations of releasing genetically-modified organisms into the wild are also discussed.

Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

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Mass Production of Genetically Modified Aedes aegypti for Field Releases in Brazil

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RNAi Trigger Delivery into Anopheles gambiae Pupae

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Learn about genetic drive strategies for controlling mosquito populations using Wolbachia pipientis. Dr. Jason Rasgon discusses how this endosymbiotic bacterium can spread beneficial genes through vector populations to combat malaria.

Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive

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