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JoVE Journal
Immunology and Infection

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Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
 

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Article DOI: 10.3791/2532
February 14th, 2011

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Summary February 14th, 2011

C57BL/6 mice have been used to study Hc pathogenesis and provide the best model. We are exploring the potential benefits of humoral immunity against this fungus and generated several mAbs [to histone H2B and a heat shock protein 60kDa] that we tested for their protective efficacy after intraperitoneal administration.

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