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JoVE Journal
Immunology and Infection

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Using Luciferase to Image Bacterial Infections in Mice
 

Using Luciferase to Image Bacterial Infections in Mice

Article DOI: 10.3791/2547
February 18th, 2011

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Summary February 18th, 2011

Methods for bioluminescence imaging of bacterial infections in living animals are decribed. Pathogens are modified to express luciferase allowing optical whole body imaging of infections in live animals. Animal models can be infected with luciferase expressing pathogens and the resulting course of disease visualized in real-time by bioluminescence imaging.

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