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JoVE Journal
Biology

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Detection of Post-translational Modifications on Native Intact Nucleosomes by ELISA
 

Detection of Post-translational Modifications on Native Intact Nucleosomes by ELISA

Article DOI: 10.3791/2593
April 26th, 2011

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Summary April 26th, 2011

Nucleosome ELISA (NU-ELISA) is a sensitive and quantitative method to detect global patterns of post-translational modifications in preparations of native, intact nucleosomes. These modifications include methylations, acetylations, and phosphorylations at specific histone amino acid residues, and hence NU-ELISA provides a global proteomic assay of the overall chromatin modification states of specific cell types.

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