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Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)

Article DOI: 10.3791/2755-v • 08:33 min • June 28th, 2011
June 28th, 2011 •
*1,2,3, *1,2,3, 1,2,3, 4, 5, 1,2,3
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, 2Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California at Los Angeles, 3California NanoSystems Institute, University of California at Los Angeles, 4Nuclear Medicine, PET Center, Shanghai Medical Collegea, Fudan University, 5Electronics and Information Engineering, College of Electronics and Information Engineering, Wuhan Textile University
* These authors contributed equally

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Summary
Automatic Translation

A facile, one-pot synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) was developed based on a non-aqueous, three-step radiochemical process. Using microwave heating, the entire procedure can be completed in less than 30 min, or 60 min with further purification by preparative HPLC. The decay-corrected radiochemical yields (RCYs) were 35-5% (n > 30).

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Microwave-assisted One-pot Synthesis N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB Biomolecules Peptides Proteins Antibodies Engineered Fragments Therapeutics Molecular Imaging Agents Positron-emitting Radioisotopes Cu-64 Ga-68 F-18 Targeted Imaging Physiological Processes Pathological Processes Synthesis Exploration 18F-labeled Biomolecules Direct 18F-labeling Organic Solvent Extreme PH High Temperature Radiolabeled Prosthetic Groups Method Of Choice Bolton-Hunter Type Reagent Primary Amino Groups In Vivo Stability Radiolabeling Yield PET Tracers
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